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Open AccessArticle

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10, Km 139.7, 2695-066 Bobadela LRS, Portugal
Departamento de Engenharia e Ciências Nucleares (DECN), Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal
Centre de Biophysique Moléculaire, CNRS, UPR 4301, Université d’Orléans, Rue Charles Sadron, 45071 Orléans CEDEX 2, France
Department of Life Sciences, Faculty of Science and TechnologyUniversity of Coimbra, Calçada Martim de Freitas, 3000-393 Coimbra, Portugal
Coimbra Chemistry Center, University of Coimbra, 3004-535 Coimbra, Portugal
CIBIT/ICNAS Instituto de Ciências Nucleares Aplicadas à Saúde. Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
Institute for Interdisciplinary Research of the University of Coimbra, 3030-789 Coimbra, Portugal
Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC/UAM, c/ Arturo Duperier 4, 28029 Madrid, Spain
Authors to whom correspondence should be addressed.
Materials 2020, 13(3), 513;
Received: 16 December 2019 / Revised: 8 January 2020 / Accepted: 20 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Targeted Drug Delivery)
Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes. View Full-Text
Keywords: gold nanoparticles; multimodality; MRI; SPECT; bombesin; PC3 tumor; radiosensitization gold nanoparticles; multimodality; MRI; SPECT; bombesin; PC3 tumor; radiosensitization
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Silva, F.; Paulo, A.; Pallier, A.; Même, S.; Tóth, É.; Gano, L.; Marques, F.; Geraldes, C.F.; Castro, M.M.C.; Cardoso, A.M.; Jurado, A.S.; López-Larrubia, P.; Lacerda, S.; Cabral Campello, M.P. Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics. Materials 2020, 13, 513.

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