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Open AccessArticle

Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration

1
French National Institute of Health and Medical Research (INSERM), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, 11 rue Humann, 67000 Strasbourg, France
2
Faculté de Chirurgie Dentaire de Strasbourg, Université de Strasbourg, 8 rue Sainte-Elisabeth, 67000 Strasbourg, France
3
Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro-Edificio I + D, C/Poeta Mariano Esquillor S/N, 50018 Zaragoza, Spain
4
Aragon Health Research Institute (IIS Aragon), 50009 Zaragoza, Spain
5
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Materials 2020, 13(14), 3087; https://doi.org/10.3390/ma13143087
Received: 18 May 2020 / Revised: 2 July 2020 / Accepted: 8 July 2020 / Published: 10 July 2020
(This article belongs to the Section Biomaterials)
The treatment of osteochondral defects remains a challenge. Four scaffolds were produced using Food and Drug Administration (FDA)-approved polymers to investigate their therapeutic potential for the regeneration of the osteochondral unit. Polycaprolactone (PCL) and poly(vinyl-pyrrolidone) (PVP) scaffolds were made by electrohydrodynamic techniques. Hydroxyapatite (HAp) and/or sodium hyaluronate (HA) can be then loaded to PCL nanofibers and/or PVP particles. The purpose of adding hydroxyapatite and sodium hyaluronate into PCL/PVP scaffolds is to increase the regenerative ability for subchondral bone and joint cartilage, respectively. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were seeded on these biomaterials. The biocompatibility of these biomaterials in vitro and in vivo, as well as their potential to support MSC differentiation under specific chondrogenic or osteogenic conditions, were evaluated. We show here that hBM-MSCs could proliferate and differentiate both in vitro and in vivo on these biomaterials. In addition, the PCL-HAp could effectively increase the mineralization and induce the differentiation of MSCs into osteoblasts in an osteogenic condition. These results indicate that PCL-HAp biomaterials combined with MSCs could be a beneficial candidate for subchondral bone regeneration. View Full-Text
Keywords: biomaterial; bone engineering; cartilage; sodium hyaluronate; hydroxyapatite; osteochondral defect; polycaprolactone; regeneration; scaffold; stem cells; subchondral bone biomaterial; bone engineering; cartilage; sodium hyaluronate; hydroxyapatite; osteochondral defect; polycaprolactone; regeneration; scaffold; stem cells; subchondral bone
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MDPI and ACS Style

Smaida, R.; Pijnenburg, L.; Irusta, S.; Himawan, E.; Mendoza, G.; Harmouch, E.; Idoux-Gillet, Y.; Kuchler-Bopp, S.; Benkirane-Jessel, N.; Hua, G. Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration. Materials 2020, 13, 3087.

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