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Materials 2019, 12(7), 1187;

A Clue to the Existence of Bonding between Bone and Implant Surface: An In Vivo Study

Division of Prosthodontics, Department of Dentistry, St. Catholic Hospital, Catholic University of Korea, Suwon 16247, Korea
Dental Research Institute, Seoul National University, Seoul 03080, Korea
Animal Facility of Aging Science, Korea Basic Science Institute, Gwangju 61186, Korea
Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 03080, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 1 April 2019 / Revised: 9 April 2019 / Accepted: 9 April 2019 / Published: 11 April 2019
(This article belongs to the Special Issue Dental Implant Materials 2019)
PDF [1179 KB, uploaded 11 April 2019]


We evaluated the shear bond strength of bone–implant contact, or osseointegration, in the rabbit tibia model, and compared the strength between grades 2 and 4 of commercially pure titanium (cp-Ti). A total of 13 grades 2 and 4 cp-Ti implants were used, which had an identical cylinder shape and surface topography. Field emission scanning electron microscopy, X-ray photoelectron spectroscopy, and confocal laser microscopy were used for surface analysis. Four grades 2 and 4 cp-Ti implants were inserted into the rabbit tibiae with complete randomization. After six weeks of healing, the experimental animals were sacrificed and the implants were removed en bloc with the surrounding bone. The bone–implant interfaces were three-dimensionally imaged with micro-computed tomography. Using these images, the bone–implant contact area was measured. Counterclockwise rotation force was applied to the implants for the measurement of removal torque values. Shear bond strength was calculated from the measured bone–implant contact and removal torque data. The t-tests were used to compare the outcome measures between the groups, and statistical significance was evaluated at the 0.05 level. Surface analysis showed that grades 2 and 4 cp-Ti implants have similar topographic features. We found no significant difference in the three-dimensional bone–implant contact area between these two implants. However, grade 2 cp-Ti implants had a higher shear bond strength than grade 4 cp-Ti implants (p = 0.032). The surfaces of the grade 2 cp-Ti implants were similar to those of the grade 4 implants in terms of physical characteristics and the quantitative amount of attachment to the bone, whereas the grade 2 surfaces were stronger than the grade 4 surfaces in the bone–surface interaction, indicating osseointegration quality. View Full-Text
Keywords: osseointegration; titanium; bone–implant interface; shear strength; torque osseointegration; titanium; bone–implant interface; shear strength; torque

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Kwon, T.-K.; Choi, J.-Y.; Park, J.-I.; Yeo, I.-S.L. A Clue to the Existence of Bonding between Bone and Implant Surface: An In Vivo Study. Materials 2019, 12, 1187.

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