Next Article in Journal
Light-Emitting Porphyrin Derivative Obtained from a Subproduct of the Cashew Nut Shell Liquid: A Promising Material for OLED Applications
Next Article in Special Issue
3D Human Periodontal Stem Cells and Endothelial Cells Promote Bone Development in Bovine Pericardium-Based Tissue Biomaterial
Previous Article in Journal
Designing and Testing Cold-Formed Rounded Connections Made on a Prototype Station
Open AccessArticle

Fluid Cartilage as New Autologous Biomaterial in the Treatment of Minor Nose Defects: Clinical and Microscopic Difference Amongst Diced, Crushed, and Fluid Cartilage

1
Department of Surgical Science University of Rome “La Sapienza”, 00161 Rome, Italy
2
FACES+ Plastic Surgery, Skin and Laser Center, La Jolla CA 92121, USA and Division of Plastic Surgery, University of California San Diego, San Diego, CA 92121, USA
3
Cell Therapy Laboratory, CBT-1409, INSERM, Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France
4
Plastic Surgery Department, Assistance Publique Hôpitaux de Marseille (APHM), Aix Marseille University, 13005 Marseille, France
5
Department of Plastic Surgery, IASO General Hospital, Athens 15562, Greece
6
Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, 00133 Rome, Italy
7
Department of Research, Advanced Diagnostic, and Technological Innovation, Regina Elena National Cancer Institute, 00144 Rome, Italy
8
Department of Plastic Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy
9
Department of Plastic Surgery Catholic University of the Sacred Heart, 00168 Rome, Italy
10
Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(7), 1062; https://doi.org/10.3390/ma12071062
Received: 1 March 2019 / Revised: 19 March 2019 / Accepted: 29 March 2019 / Published: 31 March 2019
(This article belongs to the Special Issue Biofunctionalized Scaffold in Regenerative Medicine)
Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity. View Full-Text
Keywords: fluid cartilage; minor nose defects; rhinoplasty; diced cartilage; crushing cartilage fluid cartilage; minor nose defects; rhinoplasty; diced cartilage; crushing cartilage
Show Figures

Figure 1

MDPI and ACS Style

Trivisonno, A.; Cohen, S.R.; Magalon, G.; Magalon, J.; Sterodimas, A.; Pascali, M.; Cervelli, V.; Toietta, G.; Colaprietra, A.; Calcagni, F.; Orlandi, A.; Scioli, M.G.; Gentile, P. Fluid Cartilage as New Autologous Biomaterial in the Treatment of Minor Nose Defects: Clinical and Microscopic Difference Amongst Diced, Crushed, and Fluid Cartilage. Materials 2019, 12, 1062.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop