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10.3390/ma12040567
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Article

The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films

by
Ivan Jirka
1,*,
Ivana Kopová
2,
Pavel Kubát
1,
Edyta Tabor
1,
Lucie Bačáková
2,
Milan Bouša
1 and
Petr Sajdl
3
1
J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, v.v.i, Dolejškova 3, 182 23 Prague 8, Czech Republic
2
Institute of Physiology of the Czech Academy of Sciences, v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic
3
Power Engineering Department, University of Chemistry and Technology, Technická 3, 166 28 Prague 6, Czech Republic
*
Author to whom correspondence should be addressed.
Materials 2019, 12(4), 567; https://doi.org/10.3390/ma12040567
Submission received: 4 January 2019 / Revised: 31 January 2019 / Accepted: 10 February 2019 / Published: 14 February 2019
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Abstract

We investigated the use of a supported silicalite-1 film (SF) as a promising coating for metallic materials used in the fabrication of prostheses. The role of carbonaceous residua present on high-temperature calcined-SF in generating singlet oxygen for future use as a sterilization method has also been addressed, and the potential genotoxicity of these residua in osteoblast-like cells has been investigated. Calcination of as-synthesized SF induced the appearance of a rather complicated mixture of aliphatic and aromatic species on its outer surface. A series of variously volatile polycyclic aromatic hydrocarbons (PAH), including naphthalene, fluorene, phenanthrene, anthracene, fluoranthene, and pyrene, were identified in micromole concentrations. Irradiation of these PAHs on calcined-SF immersed in air-saturated chloroform led to the formation of very low concentrations of singlet oxygen. However, an increased level of DNA damage was observed on calcined-SF by immunofluorescence staining of phosphorylated histone H2AX analyzed by flow cytometry.
Keywords: genotoxicity; surface coating; implant material; singlet oxygen genotoxicity; surface coating; implant material; singlet oxygen
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MDPI and ACS Style

Jirka, I.; Kopová, I.; Kubát, P.; Tabor, E.; Bačáková, L.; Bouša, M.; Sajdl, P. The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films. Materials 2019, 12, 567. https://doi.org/10.3390/ma12040567

AMA Style

Jirka I, Kopová I, Kubát P, Tabor E, Bačáková L, Bouša M, Sajdl P. The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films. Materials. 2019; 12(4):567. https://doi.org/10.3390/ma12040567

Chicago/Turabian Style

Jirka, Ivan, Ivana Kopová, Pavel Kubát, Edyta Tabor, Lucie Bačáková, Milan Bouša, and Petr Sajdl. 2019. "The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films" Materials 12, no. 4: 567. https://doi.org/10.3390/ma12040567

APA Style

Jirka, I., Kopová, I., Kubát, P., Tabor, E., Bačáková, L., Bouša, M., & Sajdl, P. (2019). The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films. Materials, 12(4), 567. https://doi.org/10.3390/ma12040567

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