Next Article in Journal
Microstructure Evolution and Mechanical Stability of Retained Austenite in Thermomechanically Processed Medium-Mn Steel
Next Article in Special Issue
Oxidation Protective Hybrid Coating for Thermoelectric Materials
Previous Article in Journal
Bio-Inspired 3D Infill Patterns for Additive Manufacturing and Structural Applications
Previous Article in Special Issue
Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures
Open AccessArticle

Studies on Cell Compatibility, Antibacterial Behavior, and Zeta Potential of Ag-Containing Polydopamine-Coated Bioactive Glass-Ceramic

1
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
2
Colorobbia Consulting s.r.l., 50053 Sovigliana Vinci, Florence, Italy
3
Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy
4
Centre for Medical Physics and Technology, University of Erlangen-Nuremberg, 91052 Erlangen, Germany
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(3), 500; https://doi.org/10.3390/ma12030500
Received: 23 December 2018 / Revised: 18 January 2019 / Accepted: 29 January 2019 / Published: 6 February 2019
(This article belongs to the Special Issue Advanced Glasses, Composites and Ceramics for High Growth Industries)
Dopamine is a small molecule that mimics the adhesive component (L-DOPA) of marine mussels with a catecholamine structure. Dopamine can spontaneously polymerize to form polydopamine (PDA) in a mild basic environment. PDA binds, in principle, to all types of surfaces and offers a platform for post-modification of surfaces. In this work, a novel Ag-containing polydopamine coating has been developed for the functionalization of bioactive glass-ceramics. In order to study the interactions between the surface of uncoated and coated samples and the environment, we have measured the surface zeta potential. Results confirmed that PDA can interact with the substrate through different chemical groups. A strongly negative surface zeta potential was measured, which is desirable for biocompatibility. The dual function of the material, namely the capability to exhibit bioactive behavior while being antibacterial and not harmful to mammalian cells, was assessed. The biocompatibility of the samples with MG-63 (osteoblast-like) cells was determined, as well as the antibacterial behavior against Gram-positive Staphylococcus carnosus and Gram-negative Escherichia coli bacteria. During cell biology tests, uncoated and PDA-coated samples showed biocompatibility, while cell viability on Ag-containing PDA-coated samples was reduced. On the other hand, antibacterial tests confirmed the strong antimicrobial properties of Ag-containing PDA-coated samples, although tailoring of the silver release will be necessary to modulate the dual effect of PDA and silver. View Full-Text
Keywords: polydopamine; silver; antibacterial; biocompatibility; bioactive glass-ceramic; coatings polydopamine; silver; antibacterial; biocompatibility; bioactive glass-ceramic; coatings
Show Figures

Figure 1

MDPI and ACS Style

Tejido-Rastrilla, R.; Ferraris, S.; Goldmann, W.H.; Grünewald, A.; Detsch, R.; Baldi, G.; Spriano, S.; Boccaccini, A.R. Studies on Cell Compatibility, Antibacterial Behavior, and Zeta Potential of Ag-Containing Polydopamine-Coated Bioactive Glass-Ceramic. Materials 2019, 12, 500.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop