Materials 2019, 12(3), 423; https://doi.org/10.3390/ma12030423
Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures
1
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
2
Institute of Biophysics, Department of Physics, University of Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Received: 11 January 2019 / Revised: 24 January 2019 / Accepted: 26 January 2019 / Published: 30 January 2019
(This article belongs to the Special Issue Advanced Glasses, Composites and Ceramics for High Growth Industries)
Abstract
Resorbable (Vicryl® Plus) sutures were coated with zinc-doped glass (Zn-BG) and silver-doped ordered mesoporous bioactive glass (Ag-MBG) particles by a dip coating technique. A multilayer approach was used to achieve robust coatings. The first coating was a polymeric layer (e.g., PCL or chitosan) and the second one was a composite made of BG particles in a polymer matrix. The coatings were characterized in terms of morphology by scanning electron microscopy (SEM), in vitro bioactivity, and antibacterial properties. Chitosan/Ag-MBG coatings showed the ability to form hydroxyl-carbonate-apatite on their surfaces after immersion in SBF. An antibacterial effect against Gram (+) and Gram (-) bacteria was confirmed, highlighting the potential application of the coated sutures for antibiotic-free approaches. View Full-TextKeywords:
Zinc; silver-doped mesoporous glass; chitosan; PCL; Vicryl Plus suture; dip coating
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Ciraldo, F.E.; Schnepf, K.; Goldmann, W.H.; Boccaccini, A.R. Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures. Materials 2019, 12, 423.
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