Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures
1
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
2
Institute of Biophysics, Department of Physics, University of Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Materials 2019, 12(3), 423; https://doi.org/10.3390/ma12030423
Received: 11 January 2019 / Revised: 24 January 2019 / Accepted: 26 January 2019 / Published: 30 January 2019
(This article belongs to the Special Issue Advanced Glasses, Composites and Ceramics for High Growth Industries)
Resorbable (Vicryl® Plus) sutures were coated with zinc-doped glass (Zn-BG) and silver-doped ordered mesoporous bioactive glass (Ag-MBG) particles by a dip coating technique. A multilayer approach was used to achieve robust coatings. The first coating was a polymeric layer (e.g., PCL or chitosan) and the second one was a composite made of BG particles in a polymer matrix. The coatings were characterized in terms of morphology by scanning electron microscopy (SEM), in vitro bioactivity, and antibacterial properties. Chitosan/Ag-MBG coatings showed the ability to form hydroxyl-carbonate-apatite on their surfaces after immersion in SBF. An antibacterial effect against Gram (+) and Gram (-) bacteria was confirmed, highlighting the potential application of the coated sutures for antibiotic-free approaches.
View Full-Text
Keywords:
Zinc; silver-doped mesoporous glass; chitosan; PCL; Vicryl Plus suture; dip coating
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Ciraldo, F.E.; Schnepf, K.; Goldmann, W.H.; Boccaccini, A.R. Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures. Materials 2019, 12, 423.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
