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Open AccessArticle

New Pre-reacted Glass Containing Dental Composites (giomers) with Improved Fluoride Release and Biocompatibility

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Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Str., 400000 Cluj Napoca, Romania
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Raluca Ripan Institute of Research in Chemistry, Babes Bolyai University, 30 Fintanele Str., 400294 Cluj Napoca, Romania
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Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1 Clinicilor Str., 400006 Cluj Napoca, Romania
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Department of Oral and Cranio-Maxillofacial Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, 33 Motilor Str, 40001 Cluj-Napoca, Romania
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Physical Metallurgy, Department of Metallic Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Faculty of Mathematics and Computer Science, Babes Bolyai University, 7-9 Universitatii Str., 400084 Cluj Napoca, Romania
*
Author to whom correspondence should be addressed.
Materials 2019, 12(23), 4021; https://doi.org/10.3390/ma12234021
Received: 30 October 2019 / Revised: 27 November 2019 / Accepted: 29 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Selected Papers from BIOMMEDD 2018 Conference—Biomaterials)
The aim of the present work was to prepare a series of novel restorative giomers and investigate the morphology, the physico-chemical properties (residual monomer, fluoride release), and the cytotoxicity of the new materials. The experimental giomers were prepared as light-cured pastes by blending different resin matrices comprising aromatic/aliphatic/urethane (di) methacrylates, with hybrid fillers containing pre-reacted glasses (PRGs), a radiopaque glass, and nano fluorhydroxyapatite. Polyalkenoic acids based on acrylic acid/itaconic acid/N-acryloyl -L-leucine modified or not with methacrylic groups, together with a superficially active glass, were used to prepare the PRGs. The fluoride ion release of the experimental giomers was investigated within a period of 60 days of storage in bidistilled water while using a fluoride ion selective electrode. Beautifil II commercial product was used as a reference. Cell cytotoxicity tests were done in vitro, in accordance with ISO 10993-122012 proceedings. Human dermal fibroblasts and umbilical endothelial vein cultures were used. The values that were obtained for cumulative fluoride release for all experimental giomers were higher than for the Beautifil II product, being more than twice the ones that were obtained for the commercial product after 60 days of storage in bidistilled water. The experimental biomaterials showed similar and/or better results when compared to the commercial one; this effect was maintained in all tested conditions. View Full-Text
Keywords: dental giomers; residual monomer; fluoride release; cytotoxicity; SEM dental giomers; residual monomer; fluoride release; cytotoxicity; SEM
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MDPI and ACS Style

Colceriu Burtea, L.; Prejmerean, C.; Prodan, D.; Baldea, I.; Vlassa, M.; Filip, M.; Moldovan, M.; (Moldovan), M.-A.L.; Antoniac, A.; Prejmerean, V.; Ambrosie, I. New Pre-reacted Glass Containing Dental Composites (giomers) with Improved Fluoride Release and Biocompatibility. Materials 2019, 12, 4021.

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