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Open AccessArticle

Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide

1
Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 765-8557, Japan
2
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
3
Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, Japan
*
Author to whom correspondence should be addressed.
Materials 2019, 12(22), 3681; https://doi.org/10.3390/ma12223681 (registering DOI)
Received: 29 September 2019 / Revised: 25 October 2019 / Accepted: 5 November 2019 / Published: 8 November 2019
(This article belongs to the Special Issue Absorbable Metals for Biomedical Applications)
We studied human bone healing characteristics and the histological osteogenic environment by using devices made of a composite of uncalcined and unsintered hydroxyapatite (u-HA) and poly-L-lactide (PLLA). In eight cases of fixation, we used u-HA/PLLA screws for maxillary alveolar ridge augmentation, for which mandibular cortical bone block was used in preimplantation surgery. Five appropriate samples with screws were evaluated histologically and immunohistochemically for runt-related transcription factor 2 (RUNX2), transcription factor Sp7 (Osterix), and leptin receptor (LepR). In all cases, histological evaluation revealed that bone components had completely surrounded the u-HA/PLLA screws, and the bone was connected directly to the biomaterial. Inflammatory cells did not invade the space between the bone and the u-HA/PLLA screw. Immunohistochemical evaluation revealed that many cells were positive for RUNX2 or Osterix, which are markers for osteoblast and osteoprogenitor cells, in the tissues surrounding u-HA/PLLA. In addition, many bone marrow–derived mesenchymal stem cells were notably positive for both LepR and RUNX2. The u-HA/PLLA material showed excellent bioactive osteoconductivity and a highly biocompatibility with bone directly attached. In addition, our findings suggest that many bone marrow–derived mesenchymal stem cells and mature osteoblast are present in the osteogenic environment created with u-HA/PLLA screws and that this environment is suitable for osteogenesis. View Full-Text
Keywords: poly-L-lactide; uncalcined and unsintered hydroxyapatite; biocompatibility; osteoconductivity; mesenchymal stem cell poly-L-lactide; uncalcined and unsintered hydroxyapatite; biocompatibility; osteoconductivity; mesenchymal stem cell
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Sukegawa, S.; Kawai, H.; Nakano, K.; Takabatake, K.; Kanno, T.; Nagatsuka, H.; Furuki, Y. Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide. Materials 2019, 12, 3681.

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