Next Article in Journal
Morphology of Composite [email protected] Submicron Particles, Produced with Ultrasonic Spray Pyrolysis and Potential for Synthesis of [email protected] Core–Shell Particles
Next Article in Special Issue
Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide
Previous Article in Journal
Influence of Coarse Aggregates and Silica Fume on the Mechanical Properties, Durability, and Microstructure of Concrete
Previous Article in Special Issue
Microstructure and Properties of Nano-Hydroxyapatite Reinforced WE43 Alloy Fabricated by Friction Stir Processing
Open AccessArticle

Biological Assessment of Zn–Based Absorbable Metals for Ureteral Stent Applications

1
Department of Mining, Metallurgical and Materials Engineering & CHU de Québec Research Center, Laval University, Quebec City, QC G1V 0A6, Canada
2
Centre de Recherche en Organogénèse Expérimentale/LOEX, Division of Regenerative Medicine, CHU de Québec Research Center, Laval University, Quebec City, QC G1J 1Z4, Canada
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(20), 3325; https://doi.org/10.3390/ma12203325
Received: 12 September 2019 / Revised: 1 October 2019 / Accepted: 9 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Absorbable Metals for Biomedical Applications)
The use of ureteral stents to relieve urinary tract obstruction is still challenged by the problems of infection, encrustation, and compression, leading to the need for early removal procedures. Biodegradable ureteral stents, commonly made of polymers, have been proposed to overcome these problems. Recently, absorbable metals have been considered as potential materials offering both biodegradation and strength. This work proposed zinc-based absorbable metals by firstly evaluating their cytocompatibility toward normal primary human urothelial cells using 2D and 3D assays. In the 2D assay, the cells were exposed to different concentrations of metal extracts (i.e., 10 mg/mL of Zn–1Mg and 8.75 mg/mL of Zn–0.5Al) for up to 3 days and found that their cytoskeletal networks were affected but were recovered at day 3, as observed by immunofluorescence. In the 3D ureteral wall tissue construct, the cells formed a multilayered urothelium, as found in native tissue, with the presence of tight junctions at the superficial layer and laminin at the basal layer, indicating a healthy tissue condition even with the presence of the metal samples for up to 7 days of exposure. The basal cells attached to the metal surface as seen in a natural spreading state with pseudopodia and fusiform morphologies, indicating that the metals were non-toxic. View Full-Text
Keywords: absorbable metal; cytotoxicity; stent; ureteral; urothelial cells; zinc alloy absorbable metal; cytotoxicity; stent; ureteral; urothelial cells; zinc alloy
Show Figures

Figure 1

MDPI and ACS Style

Paramitha, D.; Chabaud, S.; Bolduc, S.; Hermawan, H. Biological Assessment of Zn–Based Absorbable Metals for Ureteral Stent Applications. Materials 2019, 12, 3325.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop