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Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties

Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 9, Iroon Polytechniou str., 15780 Zografou, Greece
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Materials 2019, 12(16), 2589; https://doi.org/10.3390/ma12162589
Received: 18 July 2019 / Revised: 8 August 2019 / Accepted: 11 August 2019 / Published: 14 August 2019
(This article belongs to the Section Advanced Nanomaterials and Nanotechnology)
In this study, the synthesis of smart, polymerically embedded titanium dioxide (TiO2) nanoparticles aimed to exhibit photo-induced anticancer properties under visible light irradiation is investigated. The TiO2 nanoparticles were prepared by utilizing the sol gel method with different dopants, including nitrogen (N-doped), iron (Fe-doped), and nitrogen and iron (Fe,N-doped). The dopants were embedded in an interpenetrating (IP) network microgel synthesized by stimuli responsive poly (N-Isopropylacrylamide-co-polyacrylicacid)–pNipam-co-PAA forming composite particles. All the types of produced particles were characterized by X-ray powder diffraction, micro-Raman, Fourier-transform infrared, X-ray photoelectron, ultra-violet-visible spectroscopy, Field Emission Scanning Electron, Transmission Electron microscopy, and Dynamic Light Scattering techniques. The experimental findings indicate that the doped TiO2 nanoparticles were successfully embedded in the microgel. The N-doped TiO2 nano-powders and composite particles exhibit the best photocatalytic degradation of the pollutant methylene blue under visible light irradiation. Similarly, the highly malignant MDA-MB-231 breast cancer epithelial cells were susceptible to the inhibition of cell proliferation at visible light, especially in the presence of N-doped powders and composites, compared to the non-metastatic MCF-7 cells, which were not affected. View Full-Text
Keywords: N-doped TiO2; Fe-doped TiO2; Fe,N-doped TiO2; sol gel; IP microgel; pNiPam; drug delivery; photocatalysis; visible light; anticancer N-doped TiO2; Fe-doped TiO2; Fe,N-doped TiO2; sol gel; IP microgel; pNiPam; drug delivery; photocatalysis; visible light; anticancer
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MDPI and ACS Style

Galata, E.; Georgakopoulou, E.A.; Kassalia, M.-E.; Papadopoulou-Fermeli, N.; Pavlatou, E.A. Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties. Materials 2019, 12, 2589. https://doi.org/10.3390/ma12162589

AMA Style

Galata E, Georgakopoulou EA, Kassalia M-E, Papadopoulou-Fermeli N, Pavlatou EA. Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties. Materials. 2019; 12(16):2589. https://doi.org/10.3390/ma12162589

Chicago/Turabian Style

Galata, Evdokia; Georgakopoulou, Eleni A.; Kassalia, Maria-Emmanouela; Papadopoulou-Fermeli, Nefeli; Pavlatou, Evangelia A. 2019. "Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties" Materials 12, no. 16: 2589. https://doi.org/10.3390/ma12162589

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