Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties
AbstractIn this study, the synthesis of smart, polymerically embedded titanium dioxide (TiO2) nanoparticles aimed to exhibit photo-induced anticancer properties under visible light irradiation is investigated. The TiO2 nanoparticles were prepared by utilizing the sol gel method with different dopants, including nitrogen (N-doped), iron (Fe-doped), and nitrogen and iron (Fe,N-doped). The dopants were embedded in an interpenetrating (IP) network microgel synthesized by stimuli responsive poly (N-Isopropylacrylamide-co-polyacrylicacid)–pNipam-co-PAA forming composite particles. All the types of produced particles were characterized by X-ray powder diffraction, micro-Raman, Fourier-transform infrared, X-ray photoelectron, ultra-violet-visible spectroscopy, Field Emission Scanning Electron, Transmission Electron microscopy, and Dynamic Light Scattering techniques. The experimental findings indicate that the doped TiO2 nanoparticles were successfully embedded in the microgel. The N-doped TiO2 nano-powders and composite particles exhibit the best photocatalytic degradation of the pollutant methylene blue under visible light irradiation. Similarly, the highly malignant MDA-MB-231 breast cancer epithelial cells were susceptible to the inhibition of cell proliferation at visible light, especially in the presence of N-doped powders and composites, compared to the non-metastatic MCF-7 cells, which were not affected. View Full-Text
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Galata, E.; Georgakopoulou, E.A.; Kassalia, M.-E.; Papadopoulou-Fermeli, N.; Pavlatou, E.A. Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties. Materials 2019, 12, 2589.
Galata E, Georgakopoulou EA, Kassalia M-E, Papadopoulou-Fermeli N, Pavlatou EA. Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties. Materials. 2019; 12(16):2589.Chicago/Turabian Style
Galata, Evdokia; Georgakopoulou, Eleni A.; Kassalia, Maria-Emmanouela; Papadopoulou-Fermeli, Nefeli; Pavlatou, Evangelia A. 2019. "Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties." Materials 12, no. 16: 2589.
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