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Development of a Novel Biosensor Based on Tyrosinase/Platinum Nanoparticles/Chitosan/Graphene Nanostructured Layer with Applicability in Bioanalysis
Open AccessArticle

Development of a Graphene-Based Surface Plasmon Resonance Optical Sensor Chip for Potential Biomedical Application

1
Institute of Advanced Technology, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia
2
Faculty of Science, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Materials 2019, 12(12), 1928; https://doi.org/10.3390/ma12121928
Received: 30 April 2019 / Revised: 16 May 2019 / Accepted: 19 May 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Graphene in Biomedical Application)
The emergence of unintentional poisoning and uncontrolled vector diseases have contributed to sensor technologies development, leading to the more effective detection of diseases. In this study, we present the combination of graphene-based material with surface plasmon resonance technique. Two different graphene-based material sensor chips were prepared for rapid and quantitative detection of dengue virus (DENV) and cobalt ion (Co2+) as an example of typical metal ions. As the fundamental concept of surface plasmon resonance (SPR) sensor that relies on the refractive index of the sensor chip surface, this research focused on the SPR signal when the DENV and Co2+ interact with the graphene-based material sensor chip. The results demonstrated that the proposed sensor-based graphene layer was able to detect DENV and Co2+ as low as 0.1 pM and 0.1 ppm respectively. Further details in the detection and quantification of analyte were also discussed in terms of sensitivity, affinity, and selectivity of the sensor. View Full-Text
Keywords: graphene-based material; quantum dots; surface plasmon resonance; biosensor graphene-based material; quantum dots; surface plasmon resonance; biosensor
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MDPI and ACS Style

Omar, N.A.S.; Fen, Y.W.; Saleviter, S.; Daniyal, W.M.E.M.M.; Anas, N.A.A.; Ramdzan, N.S.M.; Roshidi, M.D.A. Development of a Graphene-Based Surface Plasmon Resonance Optical Sensor Chip for Potential Biomedical Application. Materials 2019, 12, 1928.

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