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Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide

1
College of Textiles, Donghua University, Shanghai 201620, China
2
Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
3
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(10), 1676; https://doi.org/10.3390/ma12101676
Received: 26 April 2019 / Revised: 13 May 2019 / Accepted: 20 May 2019 / Published: 23 May 2019
(This article belongs to the Special Issue Antimicrobial Nanomaterials)
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Abstract

Infection caused by bacteria in hernia repair site is a severe complication, and patients have to undergo a second surgery to remove the infected prosthesis. In this study, we developed a composite biological safe mesh with antibacterial activity. The composite mesh is composed of large pore polypropylene (PP) mesh, poly-caprolactone (PCL) and antimicrobial peptide (PEP-1), which we synthesized in our lab. Fourier transformed infrared (FTIR) spectroscopy was utilized to analyze the functional groups. The surface morphology, in vitro release characters, mechanical properties, antibacterial activities, and in vitro cytotoxicity of modified mesh were evaluated. Results showed that PEP-1 was loaded in fibers successfully and could diffuse from nanofibers to inhibit bacteria (E. coli) growth. However, the modified mesh did not show inhibition to S. aureus. The mechanical properties of fabricated mesh showed no difference with two commercial surgical meshes. What is more, modified mesh was proved to be nontoxic to human dermal fibroblasts, indicating that this method to fabricate meshes with antibacterial activity is feasible and provides a new strategy for the development of surgical meshes. View Full-Text
Keywords: antimicrobial peptide; surgical mesh; antibacterial; cytotoxicity; electrospinning; hernia repair; in vitro release; mechanical properties antimicrobial peptide; surgical mesh; antibacterial; cytotoxicity; electrospinning; hernia repair; in vitro release; mechanical properties
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Liu, P.; Chen, N.; Jiang, J.; Wen, X. Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide. Materials 2019, 12, 1676.

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