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Immobilized Enzymes in Biosensor Applications

BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahangno, Yuseong-Gu, Daejeon 34141, Korea
Department of Nanobiotechnology, KRIBB School of Biotechnology, Korea University of Science and Technology (UST), 217 Gajeongno, Yuseong-Gu, Daejeon 34113, Korea
Department of Biochemistry, College of Natural Sciences, Chungnam National University, 99 Daehangno, Yuseong-Gu, Daejeon 34134, Korea
Department of Biology, College of Arts & Sciences, Tuskegee University, Tuskegee, AL 36830, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Materials 2019, 12(1), 121;
Received: 22 November 2018 / Revised: 15 December 2018 / Accepted: 24 December 2018 / Published: 2 January 2019
(This article belongs to the Special Issue Polymeric Nanocomposites for Flexible Sensor)
Enzyme-based biosensing devices have been extensively developed over the last few decades, and have proven to be innovative techniques in the qualitative and quantitative analysis of a variety of target substrates over a wide range of applications. Distinct advantages that enzyme-based biosensors provide, such as high sensitivity and specificity, portability, cost-effectiveness, and the possibilities for miniaturization and point-of-care diagnostic testing make them more and more attractive for research focused on clinical analysis, food safety control, or disease monitoring purposes. Therefore, this review article investigates the operating principle of enzymatic biosensors utilizing electrochemical, optical, thermistor, and piezoelectric measurement techniques and their applications in the literature, as well as approaches in improving the use of enzymes for biosensors. View Full-Text
Keywords: enzyme; immobilization; biosensor; immobilized enzyme; enzyme modification enzyme; immobilization; biosensor; immobilized enzyme; enzyme modification
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MDPI and ACS Style

Nguyen, H.H.; Lee, S.H.; Lee, U.J.; Fermin, C.D.; Kim, M. Immobilized Enzymes in Biosensor Applications. Materials 2019, 12, 121.

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