Next Article in Journal
Carbon Black-Carbon Nanotube Co-Doped Polyimide Sensors for Simultaneous Determination of Ascorbic Acid, Uric Acid, and Dopamine
Next Article in Special Issue
Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study
Previous Article in Journal
Passive Q-Switching by Cr4+:YAG Saturable Absorber of Buried Depressed-Cladding Waveguides Obtained in Nd-Doped Media by Femtosecond Laser Beam Writing
Article

Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Materials 2018, 11(9), 1690; https://doi.org/10.3390/ma11091690
Received: 17 August 2018 / Revised: 27 August 2018 / Accepted: 5 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Spotlight on Bioactive Glasses and Their Related Composites)
Body-fluid-exposed bioactive glasses (BGs) integrate with living tissues due to the formation of a biomimetic surface layer of calcium hydroxy-carbonate apatite (HCA) with a close composition to bone mineral. Vast efforts have been spent to understand the mechanisms underlying in vitro apatite mineralization, as either formed by direct precipitation from supersaturated solutions, or from BG substrates in a simulated body fluid (SBF). Formally, these two scenarios are distinct and have hitherto been discussed as such. Herein, we contrast them and identify several shared features. We monitored the formation of amorphous calcium phosphate (ACP) and its crystallization into HCA from a Na 2 O–CaO–SiO 2 –P 2 O 5 glass exposed to SBF for variable periods out to 28 days. The HCA growth was assessed semi-quantitatively by Fourier transform infrared spectroscopy and powder X-ray diffraction, with the evolution of the relative apatite content for increasing SBF-exposure periods evaluated against trends in Ca and P concentrations in the accompanying solutions. This revealed a sigmoidal apatite growth behavior, well-known to apply to spontaneously precipitated apatite. The results are discussed in relation to the prevailing mechanism proposed for in vitro HCA formation from silicate-based BGs, where we highlight largely simultaneous growth processes of ACP and HCA. View Full-Text
Keywords: bioactive glass; biomimetic mineralization; apatite growth mechanism; simulated body fluid; quantification of apatite content; infrared spectroscopy; X-ray diffraction bioactive glass; biomimetic mineralization; apatite growth mechanism; simulated body fluid; quantification of apatite content; infrared spectroscopy; X-ray diffraction
Show Figures

Graphical abstract

MDPI and ACS Style

Yu, Y.; Bacsik, Z.; Edén, M. Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation. Materials 2018, 11, 1690. https://doi.org/10.3390/ma11091690

AMA Style

Yu Y, Bacsik Z, Edén M. Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation. Materials. 2018; 11(9):1690. https://doi.org/10.3390/ma11091690

Chicago/Turabian Style

Yu, Yang, Zoltán Bacsik, and Mattias Edén. 2018. "Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation" Materials 11, no. 9: 1690. https://doi.org/10.3390/ma11091690

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop