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Materials 2018, 11(11), 2223; https://doi.org/10.3390/ma11112223

Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study

1
Department of Engineering “E. Ferrari”, University of Modena and Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy
2
Laboratory of Biomaterials, Department of Medical and Surgical Sciences of Children & Adults, University of Modena and Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy
3
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Received: 14 September 2018 / Revised: 17 October 2018 / Accepted: 4 November 2018 / Published: 8 November 2018
(This article belongs to the Special Issue Spotlight on Bioactive Glasses and Their Related Composites)
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Abstract

In this work, a set of novel bioactive glasses have been tested in vivo in an animal model. The new compositions, characterized by an exceptional thermal stability and high in vitro bioactivity, contain strontium and/or magnesium, whose biological benefits are well documented in the literature. To simulate a long-term implant and to study the effect of the complete dissolution of glasses, samples were implanted in the mid-shaft of rabbits’ femur and analyzed 60 days after the surgery; such samples were in undersized powder form. The statistical significance with respect to the type of bioactive glass was analyzed by Kruskal–Wallis test. The results show high levels of bone remodeling, several new bone formations containing granules of calcium phosphate (sometimes with amounts of strontium and/or magnesium), and the absence of adverse effects on bone processes due to the almost complete glass dissolution. In vivo results confirming the cell culture outcomes of a previous study highlighted that these novel bioglasses had osteostimulative effect without adverse skeletal reaction, thus indicating possible beneficial effects on bone formation processes. The presence of strontium in the glasses seems to be particularly interesting. View Full-Text
Keywords: bioactive glasses; in vivo study; regenerative medicine; bone regeneration; strontium; magnesium bioactive glasses; in vivo study; regenerative medicine; bone regeneration; strontium; magnesium
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bellucci, D.; Cannillo, V.; Anesi, A.; Salvatori, R.; Chiarini, L.; Manfredini, T.; Zaffe, D. Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study. Materials 2018, 11, 2223.

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