Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold
AbstractThe aim of this study was to manufacture and evaluate the effect of a biphasic calcium silicophosphate (CSP) scaffold ceramic, coated with a natural demineralized bone matrix (DBM), to evaluate the efficiency of this novel ceramic material in bone regeneration. The DBM-coated CSP ceramic was made by coating a CSP scaffold with gel DBM, produced by the partial sintering of different-sized porous granules. These scaffolds were used to reconstruct defects in rabbit tibiae, where CSP scaffolds acted as the control material. Micro-CT and histological analyses were performed to evaluate new bone formation at 1, 3, and 5 months post-surgery. The present research results showed a correlation among the data obtained by micro-CT and the histomorphological results, the gradual disintegration of the biomaterial, and the presence of free scaffold fragments dispersed inside the medullary cavity occupied by hematopoietic bone marrow over the 5-month study period. No difference was found between the DBM-coated and uncoated implants. The new bone tissue inside the implants increased with implantation time. Slightly less new bone formation was observed in the DBM-coated samples, but it was not statistically significant. Both the DBM-coated and the CSP scaffolds gave excellent bone tissue responses and good osteoconductivity. View Full-Text
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Parrilla-Almansa, A.; García-Carrillo, N.; Ros-Tárraga, P.; Martínez, C.M.; Martínez-Martínez, F.; Meseguer-Olmo, L.; De Aza, P.N. Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold. Materials 2018, 11, 1580.
Parrilla-Almansa A, García-Carrillo N, Ros-Tárraga P, Martínez CM, Martínez-Martínez F, Meseguer-Olmo L, De Aza PN. Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold. Materials. 2018; 11(9):1580.Chicago/Turabian Style
Parrilla-Almansa, Andrés; García-Carrillo, Nuria; Ros-Tárraga, Patricia; Martínez, Carlos M.; Martínez-Martínez, Francisco; Meseguer-Olmo, Luis; De Aza, Piedad N. 2018. "Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold." Materials 11, no. 9: 1580.
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