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Open AccessArticle

Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer

1
Division of Orthopedic Surgery, McGill University, Montreal, QC H3G 1A4, Canada
2
Medical Faculty Mannheim, Heidelberg University, D-68167 Heidelberg, Germany
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The Research Institute of the McGill University Health Centre, Montreal, QC H3H 2L9, Canada
4
Montreal General Hospital C10.148.6, 1650 Cedar Ave, Montreal, QC H3G 1A4, Canada
*
Author to whom correspondence should be addressed.
Materials 2018, 11(9), 1485; https://doi.org/10.3390/ma11091485
Received: 30 July 2018 / Revised: 17 August 2018 / Accepted: 18 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Materials: 10th Anniversary)
The spine is the most common site of bone metastasis, often originating from prostate, lung, and breast cancers. High systemic doses of chemotherapeutics such as doxorubicin (DOX), cisplatin, or paclitaxel often have severe side effects. Surgical removal of spine metastases also leaves large defects which cannot spontaneously heal and require bone grafting. To circumvent these issues, we designed an approach for local chemotherapeutic delivery within 3D-printed scaffolds which could also potentially serve as a bone substitute. Direct treatment of prostate cancer cell line LAPC4 and patient derived spine metastases cells with 0.01 µM DOX significantly reduced metabolic activity, proliferation, migration, and spheroid growth. We then assessed uptake and release of DOX in a series of porous 3D-printed scaffolds on LAPC4 cells as well as patient-derived spine metastases cells. Over seven days, 60–75% of DOX loaded onto scaffolds could be released, which significantly reduced metabolic activity and proliferation of both LAPC4 and patient derived cells, while unloaded scaffolds had no effect. Porous 3D-printed scaffolds may provide a novel and inexpensive approach to locally deliver chemotherapeutics in a patient-specific manner at tumor resection sites. With a composite design to enhance strength and promote sustained drug release, the scaffolds could reduce systemic negative effects, enhance bone repair, and improve patient outcomes. View Full-Text
Keywords: low-cost 3D printing; nanoporous filament; bone metastases; doxorubicin; local delivery; prostate cancer; bone substitute low-cost 3D printing; nanoporous filament; bone metastases; doxorubicin; local delivery; prostate cancer; bone substitute
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Ahangar, P.; Akoury, E.; Ramirez Garcia Luna, A.S.; Nour, A.; Weber, M.H.; Rosenzweig, D.H. Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer. Materials 2018, 11, 1485.

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