Next Article in Journal
Developing and Testing of Strain-Hardening Cement-Based Composites (SHCC) in the Context of 3D-Printing
Next Article in Special Issue
Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering
Previous Article in Journal
Effect of Healing Agents on Crack Healing of Asphalt and Asphalt Mortar
Previous Article in Special Issue
Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Materials 2018, 11(8), 1374;

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA
Center of Nanotechnology, King Abdulaziz University, Jeddah, Makkah 21589, Saudi Arabia
Department of Bioengineering, Northeastern University, Boston, MA 02115, USA
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Biomechanics and Bioengineering (BMBI), UTC CNRS UMR 7338, University of Technology of Compiègne, Sorbonne University, 60203 Compiègne, France
Author to whom correspondence should be addressed.
Received: 11 June 2018 / Revised: 1 August 2018 / Accepted: 3 August 2018 / Published: 7 August 2018
(This article belongs to the Special Issue Polymeric Materials for Medical Applications)
Full-Text   |   PDF [5900 KB, uploaded 7 August 2018]   |  


Polymeric scaffolds such as hydrogels can be engineered to restore, maintain, or improve impaired tissues and organs. However, most hydrogels require surgical implantation that can cause several complications such as infection and damage to adjacent tissues. Therefore, developing minimally invasive strategies is of critical importance for these purposes. Herein, we developed several injectable cryogels made out of hyaluronic acid and gelatin for tissue-engineering applications. The physicochemical properties of hyaluronic acid combined with the intrinsic cell-adhesion properties of gelatin can provide suitable physical support for the attachment, survival, and spreading of cells. The physical characteristics of pure gelatin cryogels, such as mechanics and injectability, were enhanced once copolymerized with hyaluronic acid. Reciprocally, the adhesion of 3T3 cells cultured in hyaluronic acid cryogels was enhanced when formulated with gelatin. Furthermore, cryogels had a minimal effect on bone marrow dendritic cell activation, suggesting their cytocompatibility. Finally, in vitro studies revealed that copolymerizing gelatin with hyaluronic acid did not significantly alter their respective intrinsic biological properties. These findings suggest that hyaluronic acid-co-gelatin cryogels combined the favorable inherent properties of each biopolymer, providing a mechanically robust, cell-responsive, macroporous, and injectable platform for tissue-engineering applications. View Full-Text
Keywords: injectable; hyaluronic acid; gelatin; scaffold; cryogel; tissue engineering injectable; hyaluronic acid; gelatin; scaffold; cryogel; tissue engineering

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Rezaeeyazdi, M.; Colombani, T.; Memic, A.; Bencherif, S.A. Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications. Materials 2018, 11, 1374.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top