Next Article in Journal
Femtosecond Laser-Induced Periodic Surface Structures on Fused Silica: The Impact of the Initial Substrate Temperature
Next Article in Special Issue
Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications
Previous Article in Journal
Three-Dimensional Copper Foil-Powder Sintering Current Collector for a Silicon-Based Anode Lithium-Ion Battery
Previous Article in Special Issue
Therapeutic Contact Lenses with Polymeric Vehicles for Ocular Drug Delivery: A Review
Open AccessArticle

Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides

1
Key Laboratory of Bio-based Material Science and Technology (Ministry of Education), Northeast Forestry University, Harbin 150040, China
2
College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, China
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Materials 2018, 11(8), 1339; https://doi.org/10.3390/ma11081339
Received: 3 June 2018 / Revised: 28 July 2018 / Accepted: 30 July 2018 / Published: 2 August 2018
(This article belongs to the Special Issue Polymeric Materials for Medical Applications)
The agglomeration of silver nanoparticles (AgNPs) results in poor antibacterial performance, and the accumulation of silver in the human body threatens human health. Preparing a matrix is a technique worth considering as it not only prevents the aggregation of AgNPs but also reduces deposition of AgNPs in the human body. In this paper, carboxy-cellulose nanocrystals (CCNC) were prepared by a simple one-step acid hydrolysis method. Chito-oligosaccharides (CSos) were grafted onto the surface of CCNC to form CSos-CCNC composite nanoparticles. CCNC and CSos-CCNC were used as stabilizers for deposing AgNPs and two types of complexes—AgNPs-CCNC and AgNPs-CSos-CCNC—were obtained, respectively. The influence of the two stabilizer matrices—CCNC and CSos-CCNC—on the morphology, thermal behavior, crystal structure, antibacterial activity, and cell compatibility of AgNPs-CCNC and AgNPs-CSos-CCNC were examined. The results showed that the AgNPs deposited on the CSos-CCNC surface had a smaller average diameter and a narrower particle size distribution compared with the ones deposited on CCNC. The thermal stability of AgNPs-CSos-CCNC was better than that of AgNPs-CCNC. AgNPs did not affect the crystalline structure of CCNC and CSos-CCNC. The antibacterial activity of AgNPs-CSos-CCNC was better than that of AgNPs-CCNC based on antibacterial studies using Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. The cytotoxicity of AgNPs-CSos-CCNC was remarkably lower than that of AgNPs-CCNC. View Full-Text
Keywords: carboxy-cellulose nanocrystals; chito-oligosaccharides; silver nanoparticles; antibacterial activity; cytocompatibility carboxy-cellulose nanocrystals; chito-oligosaccharides; silver nanoparticles; antibacterial activity; cytocompatibility
Show Figures

Figure 1

MDPI and ACS Style

Ni, X.; Wang, J.; Yue, Y.; Cheng, W.; Wang, D.; Han, G. Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides. Materials 2018, 11, 1339.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop