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Functionalized Electrospun Poly(Vinyl Alcohol) Nanofibrous Membranes with Poly(Methyl Vinyl Ether-Alt-Maleic Anhydride) for Protein Adsorption

Department of Fiber Science & Apparel Design, Cornell University, Ithaca, NY 14853, USA
Author to whom correspondence should be addressed.
Materials 2018, 11(6), 1002;
Received: 12 May 2018 / Revised: 8 June 2018 / Accepted: 11 June 2018 / Published: 13 June 2018
(This article belongs to the Special Issue Electrospun Materials 2018)
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In this work, electrospun poly(vinyl alcohol) (PVA) nanofiber membranes were functionalized by incorporating poly(methyl vinyl ether-alt-maleic anhydride) (poly(MVE/MA), PMA) for the selective adsorption of proteins. The capture performance was regulated by an optimizing buffer pH, PMA content, and protein concentration. Lysozyme was used as the model protein and a high adsorption capacity of 476.53 ± 19.48 was obtained at pH 6, owing to the electrostatic attraction between the negatively charged nanofibers and positively charged proteins. The large specific surface area, highly open porous structure, and abundant available carboxyl groups contributed to such high adsorption performance. Moreover, the nanofiber membranes exhibited good reusability and good selectivity for positively charged proteins. The obtained results can provide a promising method for the purification of proteins in small analytic devices. View Full-Text
Keywords: electrospinning; protein; adsorption; separation; polymer; nanofiber electrospinning; protein; adsorption; separation; polymer; nanofiber

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Najafi, M.; Chery, J.; Frey, M.M. Functionalized Electrospun Poly(Vinyl Alcohol) Nanofibrous Membranes with Poly(Methyl Vinyl Ether-Alt-Maleic Anhydride) for Protein Adsorption. Materials 2018, 11, 1002.

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