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Materials 2018, 11(5), 754;

The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research

Biomedical Engineering Department, McGill University, 3775 Rue University, Montréal, QC H3A 2B4, Canada
Lady Davis Institute for Medical Research, Department of Medicine, McGill University, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada
Department of Bioengineering, Chemical Engineering, and Radiological Sciences, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA 90095-1600, USA
Faculty of Dentistry, McGill University, 2001 Avenue McGill College #500, Montreal, QC H3A 1G1, Canada
Author to whom correspondence should be addressed.
Received: 12 April 2018 / Revised: 29 April 2018 / Accepted: 30 April 2018 / Published: 8 May 2018
(This article belongs to the Special Issue Materials: 10th Anniversary)
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Nanoparticles are uniquely suited for the study and development of potential therapies against atherosclerosis by virtue of their size, fine-tunable properties, and ability to incorporate therapies and/or imaging modalities. Furthermore, nanoparticles can be specifically targeted to the atherosclerotic plaque, evading off-target effects and/or associated cytotoxicity. There has been a wealth of knowledge available concerning the use of nanotechnologies in cardiovascular disease and atherosclerosis, in particular in animal models, but with a major focus on imaging agents. In fact, roughly 60% of articles from an initial search for this review included examples of imaging applications of nanoparticles. Thus, this review focuses on experimental therapy interventions applied to and observed in animal models. Particular emphasis is placed on how nanoparticle materials and properties allow researchers to learn a great deal about atherosclerosis. The objective of this review was to provide an update for nanoparticle use in imaging and drug delivery studies and to illustrate how nanoparticles can be used for sensing and modelling, for studying fundamental biological mechanisms, and for the delivery of biotherapeutics such as proteins, peptides, nucleic acids, and even cells all with the goal of attenuating atherosclerosis. Furthermore, the various atherosclerosis processes targeted mainly for imaging studies have been summarized in the hopes of inspiring new and exciting targeted therapeutic and/or imaging strategies. View Full-Text
Keywords: atherosclerosis; nanoparticles; therapeutic delivery; drug delivery; imaging; targeting atherosclerosis; nanoparticles; therapeutic delivery; drug delivery; imaging; targeting

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DiStasio, N.; Lehoux, S.; Khademhosseini, A.; Tabrizian, M. The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research. Materials 2018, 11, 754.

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