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Generation of Well-Defined Micro/Nanoparticles via Advanced Manufacturing Techniques for Therapeutic Delivery

by Peipei Zhang 1,*, Junfei Xia 2 and Sida Luo 1,*
1
Department of Material Processing and Controlling, School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
2
Department of Bioengineering, Northeastern University, Boston, MA 02115, USA
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(4), 623; https://doi.org/10.3390/ma11040623
Received: 5 March 2018 / Revised: 8 April 2018 / Accepted: 11 April 2018 / Published: 18 April 2018
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
Micro/nanoparticles have great potentials in biomedical applications, especially for drug delivery. Existing studies identified that major micro/nanoparticle features including size, shape, surface property and component materials play vital roles in their in vitro and in vivo applications. However, a demanding challenge is that most conventional particle synthesis techniques such as emulsion can only generate micro/nanoparticles with a very limited number of shapes (i.e., spherical or rod shapes) and have very loose control in terms of particle sizes. We reviewed the advanced manufacturing techniques for producing micro/nanoparticles with precisely defined characteristics, emphasizing the use of these well-controlled micro/nanoparticles for drug delivery applications. Additionally, to illustrate the vital roles of particle features in therapeutic delivery, we also discussed how the above-mentioned micro/nanoparticle features impact in vitro and in vivo applications. Through this review, we highlighted the unique opportunities in generating controllable particles via advanced manufacturing techniques and the great potential of using these micro/nanoparticles for therapeutic delivery. View Full-Text
Keywords: advanced manufacturing techniques; micro/nanoparticles; controllable features; cells; in vivo; therapeutic delivery advanced manufacturing techniques; micro/nanoparticles; controllable features; cells; in vivo; therapeutic delivery
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Zhang, P.; Xia, J.; Luo, S. Generation of Well-Defined Micro/Nanoparticles via Advanced Manufacturing Techniques for Therapeutic Delivery. Materials 2018, 11, 623.

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