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Materials 2018, 11(4), 595; https://doi.org/10.3390/ma11040595

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

1
STEP@biomaterials PC, Department of Research & Development, TEPA “Lefkippos”, Patriarchou Grigoriou & Neapoleos 27, 153 41 Agia Paraskevi, Athens, Greece
2
Dental School, National and Kapodistrian University of Athens, Thivon 2, 115 27 Goudi, Athens, Greece
3
Institute of Biosciences & Application, NCSR “Demokritos”, Patriarchou Grigoriou & Neapoleos 27, 153 41 Agia Paraskevi, Athens, Greece
4
Institute of Nanoscience & Nanotechnology, NCSR “Demokritos”, Patriarchou Grigoriou & Neapoleos 27, 153 41 Agia Paraskevi, Athens, Greece
*
Author to whom correspondence should be addressed.
Received: 12 March 2018 / Revised: 3 April 2018 / Accepted: 7 April 2018 / Published: 12 April 2018
(This article belongs to the Section Biomaterials)
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Abstract

The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA—87% TCP and 41% HA—59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling. View Full-Text
Keywords: hydroxyapatite; β-tricalcium phosphate; biphasic calcium phosphates; curcumin; delivery hydroxyapatite; β-tricalcium phosphate; biphasic calcium phosphates; curcumin; delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xidaki, D.; Agrafioti, P.; Diomatari, D.; Kaminari, A.; Tsalavoutas-Psarras, E.; Alexiou, P.; Psycharis, V.; Tsilibary, E.C.; Silvestros, S.; Sagnou, M. Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies. Materials 2018, 11, 595.

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