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Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)·H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy

by Lei Xu 1, Yiran Shao 2, Chengkang Chang 1,3,* and Yingchun Zhu 2,4,*
1
School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201499, China
2
Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
3
Shanghai Innovation Institute for Materials, Shanghai University, Shanghai 200444, China
4
University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(4), 596; https://doi.org/10.3390/ma11040596
Received: 15 March 2018 / Revised: 9 April 2018 / Accepted: 10 April 2018 / Published: 12 April 2018
Tumor hypoxia is known to result in radiotherapy resistance and traditional radiotherapy using super-hard X-ray irradiation can cause considerable damage to normal tissue. Therefore, formamide peroxide (FPO) with high reactive oxygen content was employed to enhance the oxygen concentration in tumor cells and increase the radio-sensitivity of low-energy soft-X-ray. To improve stability of FPO, FPO is encapsulated into polyacrylic acid (PAA)-coated hollow mesoporous silica nanoparticles ([email protected]). On account of the pH-responsiveness of PAA, [email protected] will release more FPO in simulated acidic tumor microenvironment (pH 6.50) and subcellular endosomes (pH 5.0) than in simulated normal tissue media (pH 7.40). When exposed to soft-X-ray irradiation, the released FPO decomposes into oxygen and the generated oxygen further formed many reactive oxygen species (ROS), leading to significant tumor cell death. The ROS-mediated cytotoxicity of [email protected] was confirmed by ROS-induced green fluorescence in tumor cells. The presented FPO delivery system with soft-X-ray irradiation paves a way for developing the next opportunities of radiotherapy toward efficient tumor prognosis. View Full-Text
Keywords: formamide peroxide; ROS; soft-X-ray radiotherapy; tumor hypoxia formamide peroxide; ROS; soft-X-ray radiotherapy; tumor hypoxia
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Xu, L.; Shao, Y.; Chang, C.; Zhu, Y. Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)·H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy. Materials 2018, 11, 596.

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