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Open AccessArticle

Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material

1
Applied Medical Science Department, Community College, King Saud University, Riyadh 11437, Saudi Arabia
2
Department of Biomedical Engineering, Faculty of Engineering, Helwan University, Helwan 11792, Egypt
3
Maxillofacial Surgery Department, Dental Faculty, King Saud University, Riyadh 11545, Saudi Arabia
4
Chemical Engineering Department, King Saud University, Riyadh 11421, Saudi Arabia
5
Deanship of Graduate Studies, Saudi Electronic University, Riyadh 11637, Saudi Arabia
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Material Science Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia
7
Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia
8
Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11437, Saudi Arabia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Materials 2018, 11(4), 521; https://doi.org/10.3390/ma11040521
Received: 24 February 2018 / Revised: 26 March 2018 / Accepted: 27 March 2018 / Published: 29 March 2018
(This article belongs to the Special Issue Advanced Functional Nanomaterials and Their Applications)
In this study, porous polyethylene scaffolds were examined as bone substitutes in vitro and in vivo in critical-sized calvarial bone defects in transgenic Sprague-Dawley rats. A microscopic examination revealed that the pores appeared to be interconnected across the material, making them suitable for cell growth. The creep recovery behavior of porous polyethylene at different loads indicated that the creep strain had two main portions. In both portions, strain increased with increased applied load and temperature. In terms of the thermographic behavior of the material, remarkable changes in melting temperature and heat fusion were revealed with increased the heating rates. The tensile strength results showed that the material was sensitive to the strain rate and that there was adequate mechanical strength to support cell growth. The in vitro cell culture results showed that human bone marrow mesenchymal stem cells attached to the porous polyethylene scaffold. Calcium sulfate–hydroxyapatite (CS–HA) coating of the scaffold not only improved attachment but also increased the proliferation of human bone marrow mesenchymal stem cells. In vivo, histological analysis showed that the study groups had active bone remodeling at the border of the defect. Bone regeneration at the border was also evident, which confirmed that the polyethylene acted as an osteoconductive bone graft. Furthermore, bone formation inside the pores of the coated polyethylene was also noted, which would enhance the process of osteointegration. View Full-Text
Keywords: porous polyethylene; hydroxyapatite; mesenchymal stem cells porous polyethylene; hydroxyapatite; mesenchymal stem cells
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Fouad, H.; AlFotawi, R.; Alothman, O.Y.; Alshammari, B.A.; Alfayez, M.; Hashem, M.; Mahmood, A. Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material. Materials 2018, 11, 521.

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