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Open AccessArticle

Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

1
Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
3
Southern China Branch, Sinopec Commercial Holding Company Limited, Guangzhou 510630, China
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(2), 281; https://doi.org/10.3390/ma11020281
Received: 30 December 2017 / Revised: 31 January 2018 / Accepted: 6 February 2018 / Published: 11 February 2018
There are several challenges involved in the development of effective anti-cancer drugs, including accurate drug delivery without toxic side effects. Possible systemic toxicity and the rapid biodegradation of drug carriers are potential risks in the use of carriers for drug-delivery formulations. Therefore, the carrier-free drug delivery of an anti-cancer drug is desirable. Herein, 4-amino-2-benzyl-6-methylpyrimidine (ABMP) was synthesized via a new method using a sodium catalyst, and proved to be effective in inducing breast cancer cell (MDA-MB-231) apoptosis. Moreover, the transparent amorphous state solid of ABMP was demonstrated to have a slow-release property in phosphate buffer solution (PBS). Microspheres of ABMP were prepared with diameters in the range of 5–15 μm. The slow-release property of the ABMP microspheres indicated their potential use for controlled-release drug delivery. We believe that microspheres of ABMP have potential as a new kind of carrier-free anti-cancer drug delivery system. View Full-Text
Keywords: carrier-free; 4-amino-2-benzyl-6-methylpyrimidine; biomaterial; drug delivery carrier-free; 4-amino-2-benzyl-6-methylpyrimidine; biomaterial; drug delivery
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MDPI and ACS Style

Xie, Y.; Ma, X.; Liu, X.; Long, Q.; Wang, Y.; Yao, Y.; Cai, Q. Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery. Materials 2018, 11, 281.

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