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Open AccessArticle

In Vivo Evaluation of 3D-Printed Polycaprolactone Scaffold Implantation Combined with β-TCP Powder for Alveolar Bone Augmentation in a Beagle Defect Model

Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, Daejeon 34103, Korea
Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea
Department of Periodontology, Dankook University, Yongin-si 16890, Korea
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Materials 2018, 11(2), 238;
Received: 21 November 2017 / Revised: 20 January 2018 / Accepted: 31 January 2018 / Published: 4 February 2018
(This article belongs to the Special Issue Polymeric Materials for Medical Applications)
Insufficient bone volume is one of the major challenges encountered by dentists after dental implant placement. This study aimed to evaluate the efficacy of a customized three-dimensional polycaprolactone (3D PCL) scaffold implant fabricated with a 3D bio-printing system to facilitate rapid alveolar bone regeneration. Saddle-type bone defects were surgically created on the healed site after extracting premolars from the mandibles of four beagle dogs. The defects were radiologically examined using computed tomography for designing a customized 3D PCL scaffold block to fit the defect site. After fabricating 3D PCL scaffolds using rapid prototyping, the scaffolds were implanted into the alveolar bone defects along with β-tricalcium phosphate powder. In vivo analysis showed that the PCL blocks maintained the physical space and bone conductivity around the defects. In addition, no inflammatory infiltrates were observed around the scaffolds. However, new bone formation occurred adjacent to the scaffolds, rather than directly in contact with them. More new bone was observed around PCL blocks with 400/1200 lattices than around blocks with 400/400 lattices, but the difference was not significant. These results indicated the potential of 3D-printed porous PCL scaffolds to promote alveolar bone regeneration for defect healing in dentistry. View Full-Text
Keywords: 3D printing; polycaprolactone; beta tricalcium phosphate; dentistry 3D printing; polycaprolactone; beta tricalcium phosphate; dentistry
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Park, S.A.; Lee, H.-J.; Kim, K.-S.; Lee, S.J.; Lee, J.-T.; Kim, S.-Y.; Chang, N.-H.; Park, S.-Y. In Vivo Evaluation of 3D-Printed Polycaprolactone Scaffold Implantation Combined with β-TCP Powder for Alveolar Bone Augmentation in a Beagle Defect Model. Materials 2018, 11, 238.

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