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Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique

Department of Engineering, University of Campania “Luigi Vanvitelli”, via Roma 29, I-81031 Aversa, Italy
Department of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Ecoricerche srl, via Principi Normanni 36, 81043 Capua Caserta, Italy
Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126 Naples, Italy
Author to whom correspondence should be addressed.
Materials 2018, 11(11), 2270;
Received: 11 October 2018 / Revised: 6 November 2018 / Accepted: 10 November 2018 / Published: 14 November 2018
(This article belongs to the Special Issue Green Composites: Preparation, Properties, and Applications)
PDF [2423 KB, uploaded 14 November 2018]


The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO2 matrix, we embedded different weight percentages of polyethylene glycol (PEG6, 12, 24 wt%) and ferrous citrate (Fe(II)C5, 10, 15 wt%) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe2+ released was detected by Ultraviolet–Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, E. coli and P. aeruginosa, were investigated. View Full-Text
Keywords: sol-gel; ferrous citrate; FTIR analysis; drug release; antibacterial properties sol-gel; ferrous citrate; FTIR analysis; drug release; antibacterial properties

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Catauro, M.; Tranquillo, E.; Barrino, F.; Blanco, I.; Dal Poggetto, F.; Naviglio, D. Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique. Materials 2018, 11, 2270.

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