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Open AccessArticle

Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property

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Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
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Medical Device Innovation Center, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
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Department of Materials Science, National University of Tainan, Tainan 700, Taiwan
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Author to whom correspondence should be addressed.
Materials 2017, 10(7), 726; https://doi.org/10.3390/ma10070726
Received: 18 May 2017 / Revised: 12 June 2017 / Accepted: 28 June 2017 / Published: 30 June 2017
Porous titanium (P_Ti) is considered as an effective material for bone scaffold to achieve a stiffness reduction. Herein, biomimetic (bio-)scaffolds were made of sintered P_Ti, which used NaCl as the space holder and had it removed via the hydrothermal method. X-ray diffraction results showed that the subsequent sintering temperature of 1000 °C was the optimized temperature for preparing P_Ti. The compressive strength of P_Ti was measured using a compression test, which revealed an excellent load-bearing ability of above 70 MPa for that with an addition of 50 wt % NaCl (P_Ti_50). The nano-hardness of P_Ti, tested upon their solid surface, was presumably consistent with the density of pores vis-à-vis the addition of NaCl. Overall, a load-bearable P_Ti with a highly porous structure (e.g., P_Ti_50 with a porosity of 43.91% and a pore size around 340 μm) and considerable compressive strength could be obtained through the current process. Cell proliferation (MTS) and lactate dehydrogenase (LDH) assays showed that all P_Ti samples exhibited high cell affinity and low cell mortality, indicating good biocompatibility. Among them, P_Ti_50 showed relatively good in-cell morphology and viability, and is thus promising as a load-bearable bio-scaffold. View Full-Text
Keywords: porous titanium; biomimetic scaffold; load bearable; cell affinity porous titanium; biomimetic scaffold; load bearable; cell affinity
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MDPI and ACS Style

Lee, H.; Liao, J.-D.; Sivashanmugan, K.; Liu, B.H.-C.; Su, Y.-H.; Yao, C.-K.; Juang, Y.-D. Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property. Materials 2017, 10, 726.

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