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Open AccessArticle

The Biological Properties of OGI Surfaces Positively Act on Osteogenic and Angiogenic Commitment of Mesenchymal Stem Cells

Department of Neurosciences, Dental School, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
Centre for Integrative Biology (CIBIO), University of Trento, 38122 Trento, Italy
Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58, 35100 Padova, Italy
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
Private Practice, 09100 Milano, Italy
CLC Scientific, via Vecchia Ferriera 18, 36100 Vicenza, Italy
Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola (RA), Italy
Author to whom correspondence should be addressed.
Materials 2017, 10(11), 1321;
Received: 11 October 2017 / Revised: 6 November 2017 / Accepted: 10 November 2017 / Published: 17 November 2017
(This article belongs to the Special Issue Dental Implant Materials)
Osteogenesis process displays a fundamental role during dental implant osteointegration. In the present work, we studied the influence of Osteon Growth Induction (OGI) surface properties on the angiogenic and osteogenic behaviors of Mesenchymal Stem cells (MSC). MSC derived from dental pulp and HUVEC (Human Umbilical Vein Endothelial Cells) were grown in on OGI titanium surfaces, and cell proliferation and DNA synthesis were evaluated by MTT [3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide] test and DNA quantification. Gene expression has been performed in order to evaluate the presence of mRNA related to endothelial and osteogenesis markers. Moreover, morphological and biochemical analyses of osteogenesis commitments has been performed. On OGI surfaces, MSC and HUVEC are able to proliferate. Gene expression profiler confirms that MSC on OGI surfaces are able to express endothelial and osteogenic markers, and that these expression are higher compared the expression on control surfaces. In conclusion On OGI surfaces proliferation, expression and morphological analyses of angiogenesis-associated markers in MSC are promoted. This process induces an increasing on their osteogenesis commitment. View Full-Text
Keywords: titanium surface; dental implant; MSC titanium surface; dental implant; MSC
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Ghensi, P.; Bressan, E.; Gardin, C.; Ferroni, L.; Soldini, M.C.; Mandelli, F.; Soldini, C.; Zavan, B. The Biological Properties of OGI Surfaces Positively Act on Osteogenic and Angiogenic Commitment of Mesenchymal Stem Cells. Materials 2017, 10, 1321.

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