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Open AccessArticle

Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres

1
Department of Biomedical Engineering, Korea University, Seoul 02841, Korea
2
Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
Materials 2017, 10(10), 1110; https://doi.org/10.3390/ma10101110
Received: 16 August 2017 / Revised: 15 September 2017 / Accepted: 17 September 2017 / Published: 21 September 2017
(This article belongs to the Section Biomaterials)
This study demonstrates the utility of the newly developed self-assembly-induced gelation technique for the synthesis of porous collagen/hydroxyapatite (HA) composite microspheres with a nanofibrous structure. This new approach can produce microspheres of a uniform size using the droplets that form at the nozzle tip before gelation. These microspheres can have a highly nanofibrous structure due to the immersion of the droplets in a coagulation bath (water/acetone), in which the collagen aggregates in the solution can self-assemble into fibrils due to pH-dependent precipitation. Bioactive HA particles were incorporated into the collagen solutions, in order to enhance the bioactivity of the composite microspheres. The composite microspheres exhibited a well-defined spherical morphology and a uniform size for all levels of HA content (0 wt %, 10 wt %, 15 wt %, and 20 wt %). Collagen nanofibers—several tens of nanometers in size—were uniformly present throughout the microspheres and the HA particles were also well dispersed. The in vitro apatite-forming ability, assessed using the simulated body fluid (SBF) solution, increased significantly with the incorporation of HA into the composite microspheres. View Full-Text
Keywords: biomaterials; porous scaffolds; collagen; hydroxyapatite; in vitro bioactivity biomaterials; porous scaffolds; collagen; hydroxyapatite; in vitro bioactivity
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MDPI and ACS Style

Choi, J.-W.; Kim, J.-W.; Jo, I.-H.; Koh, Y.-H.; Kim, H.-E. Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres. Materials 2017, 10, 1110.

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