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Materials 2017, 10(1), 26;

Novel Dental Adhesive with Biofilm-Regulating and Remineralization Capabilities

State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China
Biomaterials & Tissue Engineering Division, Department of Endodontics, Periodontics and Prosthodontics, University of Maryland Dental School, Baltimore, MD 21201, USA
Authors to whom correspondence should be addressed.
Academic Editor: Aldo R. Boccaccini
Received: 7 November 2016 / Revised: 18 December 2016 / Accepted: 26 December 2016 / Published: 3 January 2017
(This article belongs to the Section Biomaterials)
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The mechanical properties and anti-caries effect of a novel anti-caries adhesive containing poly (amidoamine) dendrimer (PAMAM) and dimethylaminododecyl methacrylate (DMADDM) were investigated for the first time. Microtensile bond strength and surface charge density were measured for the novel anti-caries adhesives. Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii were chosen to form three-species biofilms. Lactic acid assay, MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, exopolysaccharide staining and live/dead staining were performed to study anti-biofilm effect of the adhesive. The TaqMan realtime polymerase chain reaction was used to study the proportion change in three-species biofilms of different groups. The Scanning Electron Microscope (SEM) was used to observe the remineralization effect of PAMAM and DMADDM. The results showed that incorporating PAMAM and DMADDM into adhesive had no adverse effect on the dentin bond strength. The 1% PAMAM and 5% DMADDM adhesive group showed anti-biofilm properties and developed a healthier biofilm with a lower chance of inducing dental caries. Combination of 1% PAMAM and 5% DMADDM solution maintained remineralization capability on dentin, similar to that using 1% PAMAM alone. In conclusion, the adhesive containing PAMAM and DMADDM had strong antimicrobial properties and biological remineralization capabilities, and is promising for anti-caries clinical applications. View Full-Text
Keywords: dental caries; adhesive; quaternary ammonium monomers; poly (amidoamine) dendrimer; dimethylaminododecyl methacrylate dental caries; adhesive; quaternary ammonium monomers; poly (amidoamine) dendrimer; dimethylaminododecyl methacrylate

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Ge, Y.; Ren, B.; Zhou, X.; Xu, H.H.K.; Wang, S.; Li, M.; Weir, M.D.; Feng, M.; Cheng, L. Novel Dental Adhesive with Biofilm-Regulating and Remineralization Capabilities. Materials 2017, 10, 26.

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