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Review

An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer

by
Gerardo Rosati
1,*,
Michele Montrone
2,
Carmen Pacilio
3,
Alfredo Colombo
4,
Giuseppe Cicero
5,
Fernando Paragliola
1,
Angelo Vaia
1,
Luigi Annunziata
1 and
Domenico Bilancia
1
1
Medical Oncology Unit, “San Carlo” Hospital, 85100 Potenza, Italy
2
Medical Thoracic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
3
Medical Breast Cancer Department, IRCCS Istituto Tumori “G. Pascale”, 80131 Napoli, Italy
4
Medical Oncology Unit, CDC Macchiarella, 90138 Palermo, Italy
5
Medical Oncology, Università degli Studi di Palermo, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(23), 7108; https://doi.org/10.3390/jcm11237108
Submission received: 1 October 2022 / Revised: 10 November 2022 / Accepted: 27 November 2022 / Published: 30 November 2022
(This article belongs to the Section Oncology)
Review Reports Versions Notes

Abstract

Although colorectal cancer is increasingly being diagnosed in older patients, their number is largely underrepresented in phase II or III clinical trials. Consequently, guidelines and the SIOG recommendations are not sufficiently clear regarding the treatment of these patients, particularly when chemotherapy is combined with monoclonal antibodies (bevacizumab, cetuximab, and panitumumab). Targeted therapy based on the use of anti-epidermal growth factor receptors (EGFRs) is conditioned by the potential for increased toxicity, making it more difficult to treat an older, rat sarcoma virus (RAS) and B rapidly accelerated fibrosarcoma (BRAF) wild-type patient. In light of a more detailed characterization of the older population, modernly differentiable between fit, vulnerable, or frail patients on the basis of the comprehensive geriatric assessment, and of the analysis of more recent studies, this review fully collects data from the literature, differentiating the results on functional status patients.
Keywords: cetuximab; metastatic colorectal cancer; older patients; panitumumab cetuximab; metastatic colorectal cancer; older patients; panitumumab

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MDPI and ACS Style

Rosati, G.; Montrone, M.; Pacilio, C.; Colombo, A.; Cicero, G.; Paragliola, F.; Vaia, A.; Annunziata, L.; Bilancia, D. An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer. J. Clin. Med. 2022, 11, 7108. https://doi.org/10.3390/jcm11237108

AMA Style

Rosati G, Montrone M, Pacilio C, Colombo A, Cicero G, Paragliola F, Vaia A, Annunziata L, Bilancia D. An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer. Journal of Clinical Medicine. 2022; 11(23):7108. https://doi.org/10.3390/jcm11237108

Chicago/Turabian Style

Rosati, Gerardo, Michele Montrone, Carmen Pacilio, Alfredo Colombo, Giuseppe Cicero, Fernando Paragliola, Angelo Vaia, Luigi Annunziata, and Domenico Bilancia. 2022. "An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer" Journal of Clinical Medicine 11, no. 23: 7108. https://doi.org/10.3390/jcm11237108

APA Style

Rosati, G., Montrone, M., Pacilio, C., Colombo, A., Cicero, G., Paragliola, F., Vaia, A., Annunziata, L., & Bilancia, D. (2022). An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer. Journal of Clinical Medicine, 11(23), 7108. https://doi.org/10.3390/jcm11237108

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