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Current Oncology
Volume 31
Issue 12
10.3390/curroncol31120592
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Review

Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer

by
Laura R. Moffitt
1,2,
Nazanin Karimnia
1,2,
Amy L. Wilson
1,2,
Andrew N. Stephens
1,2,
Gwo-Yaw Ho
3,4 and
Maree Bilandzic
1,2,*
1
Hudson Institute of Medical Research, Clayton 3168, Australia
2
Department of Molecular and Translational Sciences, Monash University, Clayton 3168, Australia
3
School of Clinical Sciences, Monash University, Clayton 3168, Australia
4
Department of Oncology, Monash Health, Bentleigh 3165, Australia
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2024, 31(12), 8023-8038; https://doi.org/10.3390/curroncol31120592
Submission received: 26 November 2024 / Revised: 13 December 2024 / Accepted: 16 December 2024 / Published: 18 December 2024
(This article belongs to the Special Issue Ovarian Cancer in the Age of Precision Medicine)
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Abstract

Precision medicine has revolutionised targeted cancer treatments; however, its implementation in ovarian cancer remains challenging. Diverse tumour biology and extensive heterogeneity in ovarian cancer can limit the translatability of genetic profiling and contribute to a lack of biomarkers of treatment response. This review addresses the barriers in precision medicine for ovarian cancer, including obtaining adequate and representative tissue samples for analysis, developing functional and standardised screening methods, and navigating data infrastructure and management. Ethical concerns related to patient consent, data privacy and health equity are also explored. We highlight the socio-economic complexities for precision medicine and propose strategies to overcome these challenges with an emphasis on accessibility and education amongst patients and health professionals and the development of regulatory frameworks to support clinical integration. Interdisciplinary collaboration is essential to drive progress in precision medicine to improve disease management and ovarian cancer patient outcomes.
Keywords: precision medicine; epithelial ovarian cancer; tumour heterogeneity; genomic screening; high-throughput drug screening precision medicine; epithelial ovarian cancer; tumour heterogeneity; genomic screening; high-throughput drug screening

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MDPI and ACS Style

Moffitt, L.R.; Karimnia, N.; Wilson, A.L.; Stephens, A.N.; Ho, G.-Y.; Bilandzic, M. Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer. Curr. Oncol. 2024, 31, 8023-8038. https://doi.org/10.3390/curroncol31120592

AMA Style

Moffitt LR, Karimnia N, Wilson AL, Stephens AN, Ho G-Y, Bilandzic M. Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer. Current Oncology. 2024; 31(12):8023-8038. https://doi.org/10.3390/curroncol31120592

Chicago/Turabian Style

Moffitt, Laura R., Nazanin Karimnia, Amy L. Wilson, Andrew N. Stephens, Gwo-Yaw Ho, and Maree Bilandzic. 2024. "Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer" Current Oncology 31, no. 12: 8023-8038. https://doi.org/10.3390/curroncol31120592

APA Style

Moffitt, L. R., Karimnia, N., Wilson, A. L., Stephens, A. N., Ho, G.-Y., & Bilandzic, M. (2024). Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer. Current Oncology, 31(12), 8023-8038. https://doi.org/10.3390/curroncol31120592

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