Severe Fatal Mucormycosis in a Patient with Chronic Lymphocytic Leukaemia Treated with Zanubrutinib: A Case Report and Review of the Literature
Abstract
:1. Introduction
2. Detailed Case Description
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Non-Immunological Risk Factors | Immunological Risk Factors | Special and Novel Risk Factors |
---|---|---|
Decompensated diabetes mellitus and ketoacidosis [31,32,33] | Immunodepression Primitive: solid and/or hematologic malignancies; autoimmunity | Premature neonates [34] |
Iron overload | ||
Major trauma | ||
Prolonged use of corticosteroids | ||
Intravenous drug abuse [27] | ||
Iatrogenic/secondary: hematopoietic stem cell (HSCT); solid organ transplant | Preventive or therapeutic antimycotic drugs (voriconazole, itraconazole, or caspofungin) [35] | |
BTK inhibitor [12,15,16,17,18,19] | ||
SARS-CoV-2 infecion and treatment [28,29] |
2006 | FCR protocol (Fludarabine-Cyclophosphamide-Rituximab) |
2010 | FCR |
2012 | Rituximab |
2013 | Bendamustine |
2014–2016 | Ibrutinib (discontinued due to infections) |
2017–2020 | Venetoclax |
2020 | Idelalisib-Rituximab |
May 2020 | Zanubrutinib |
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Maggioni, G.; Fedrigo, M.; Visentin, A.; Carturan, E.; Ruocco, V.; Trentin, L.; Alaibac, M.; Angelini, A. Severe Fatal Mucormycosis in a Patient with Chronic Lymphocytic Leukaemia Treated with Zanubrutinib: A Case Report and Review of the Literature. Curr. Oncol. 2023, 30, 8255-8265. https://doi.org/10.3390/curroncol30090599
Maggioni G, Fedrigo M, Visentin A, Carturan E, Ruocco V, Trentin L, Alaibac M, Angelini A. Severe Fatal Mucormycosis in a Patient with Chronic Lymphocytic Leukaemia Treated with Zanubrutinib: A Case Report and Review of the Literature. Current Oncology. 2023; 30(9):8255-8265. https://doi.org/10.3390/curroncol30090599
Chicago/Turabian StyleMaggioni, Giuseppe, Marny Fedrigo, Andrea Visentin, Elisa Carturan, Valeria Ruocco, Livio Trentin, Mauro Alaibac, and Annalisa Angelini. 2023. "Severe Fatal Mucormycosis in a Patient with Chronic Lymphocytic Leukaemia Treated with Zanubrutinib: A Case Report and Review of the Literature" Current Oncology 30, no. 9: 8255-8265. https://doi.org/10.3390/curroncol30090599
APA StyleMaggioni, G., Fedrigo, M., Visentin, A., Carturan, E., Ruocco, V., Trentin, L., Alaibac, M., & Angelini, A. (2023). Severe Fatal Mucormycosis in a Patient with Chronic Lymphocytic Leukaemia Treated with Zanubrutinib: A Case Report and Review of the Literature. Current Oncology, 30(9), 8255-8265. https://doi.org/10.3390/curroncol30090599