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Case Report

Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma

1
Clinical Service of Pathology, Department of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania
2
Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, “Ovidius” University of Constanta, 900591 Constanta, Romania
3
Academy of Medical Sciences of Romania, 030167 Bucuresti, Romania
4
Department of Pathology, Faculty of Medicine, “Ovidius” University of Constanta, 900470 Constanta, Romania
5
Clinical Service of Pathology, Department of Genetics, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(8), 5316-5323; https://doi.org/10.3390/curroncol29080422
Received: 27 June 2022 / Revised: 14 July 2022 / Accepted: 27 July 2022 / Published: 28 July 2022
(This article belongs to the Section Neuro-Oncology)
Giant cell glioblastoma is a rare tumor entity of IDH-wildtype glioblastoma. It is usually found in the pediatric population. We describe a particular case of a female patient diagnosed histopathologically with giant cell glioblastoma, who had two recurrences in different lobes of the same cerebral hemisphere, despite positive prognostic factors and appropriate treatment. We performed an immunohistochemical characterization of giant cell glioblastoma as well as an analysis of its aggressiveness using the cytogenetic markers TP53, CDKN2A, and TP73 using the FISH technique. The clinical picture was inconsistant, the suspicion being completely different initially. Paraclinical examination and imaging initially suggested a metastasis to the insular lobe. After surgery, histopathological and immunohistochemical examinations were the basis for the diagnosis. Despite the prognostic factors known so far in the literature, the aggressiveness denoted by multiple relapses and morphogenetic tests particularizes the case and improves the literature by bringing new information about this rare neoplasm of the central nervous system. View Full-Text
Keywords: CDKN2A; giant cell glioblastoma; imaging; immunohistochemistry; TP53 CDKN2A; giant cell glioblastoma; imaging; immunohistochemistry; TP53
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MDPI and ACS Style

Orasanu, C.I.; Aschie, M.; Deacu, M.; Mocanu, L.; Voda, R.I.; Topliceanu, T.S.; Cozaru, G.C. Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma. Curr. Oncol. 2022, 29, 5316-5323. https://doi.org/10.3390/curroncol29080422

AMA Style

Orasanu CI, Aschie M, Deacu M, Mocanu L, Voda RI, Topliceanu TS, Cozaru GC. Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma. Current Oncology. 2022; 29(8):5316-5323. https://doi.org/10.3390/curroncol29080422

Chicago/Turabian Style

Orasanu, Cristian Ionut, Mariana Aschie, Mariana Deacu, Liliana Mocanu, Raluca Ioana Voda, Theodor Sebastian Topliceanu, and Georgeta Camelia Cozaru. 2022. "Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma" Current Oncology 29, no. 8: 5316-5323. https://doi.org/10.3390/curroncol29080422

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