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Current Oncology
Volume 29
Issue 7
10.3390/curroncol29070372
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Article

Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers

by
Alma D. Campos-Parra
1,†,
Milagros Pérez-Quintanilla
2,†,
Antonio Daniel Martínez-Gutierrez
1,
Delia Pérez-Montiel
3,
Jaime Coronel-Martínez
2,
Oliver Millan-Catalan
1,
David Cantú De León
2,* and
Carlos Pérez-Plasencia
1,4,*
1
Laboratorio de Genómica, Instituto Nacional de Cancerología (INCan), Mexico City 14080, Mexico
2
Unidad de Investigaciones Biomédicas en Cancer, Instituto Nacional de Cancerología (INCan), Universidad Nacional Autónoma de México (UNAM), Av San Fernando 22, Col. Sección XVI, Mexico City 14080, Mexico
3
Departamento de Patología, Instituto Nacional de Cancerología (INCan), Mexico City 14080, Mexico
4
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla de Baz 54090, Mexico
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Oncol. 2022, 29(7), 4689-4702; https://doi.org/10.3390/curroncol29070372
Submission received: 30 March 2022 / Revised: 23 June 2022 / Accepted: 28 June 2022 / Published: 5 July 2022
(This article belongs to the Special Issue New Frontiers in Treatment for Gynecologic Cancers)
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Abstract

The most frequently diagnosed histological types of cervical cancer (CC) are squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Clinically, the prognosis of both types is controversial. A molecular profile that distinguishes each histological subtype and predicts the prognosis would be of great benefit to CC patients. Methods: The transcriptome of CC patients from The Cancer Genome Atlas (TCGA) was analyzed using the DESeq2 package to obtain the differentially expressed genes (DEGs) between ADC and SCC. The DEGs were validated on a publicly available Mexican-Mestizo patient transcriptome dataset (GSE56303). The global biological pathways involving the DEGs were obtained using the Webgestalt platform. The associations of the DEGs with Overall Survival (OS) were assessed. Finally, three DEGs were validated by RT-qPCR in an independent cohort of Mexican patients. Results. The molecular profiles of ADC and SCC of the CC patients of the TCGA database and the Mexican-Mestizo cohort (GSE56303) were determined obtaining 1768 and 88 DEGs, respectively. Strikingly, 70 genes were concordant—with similar Log2FoldChange values—in both cohorts. The 70 DEGs were involved in IL-17, JAK/STAT, and Ras signaling. Kaplan-Meier OS analysis from the Mexican-Mestizo cohort showed that higher GABRB2 and TSPAN8 and lower TMEM40 expression were associated with better OS. Similar results were found in an independent Mexican cohort. Conclusions: Molecular differences were detected between the ADC and SCC subtypes; however, further studies are required to define the appropriate prognostic biomarker for each histological type.
Keywords: cervical cancer; adenocarcinoma; squamous cell carcinoma cervical cancer; adenocarcinoma; squamous cell carcinoma

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MDPI and ACS Style

Campos-Parra, A.D.; Pérez-Quintanilla, M.; Martínez-Gutierrez, A.D.; Pérez-Montiel, D.; Coronel-Martínez, J.; Millan-Catalan, O.; De León, D.C.; Pérez-Plasencia, C. Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers. Curr. Oncol. 2022, 29, 4689-4702. https://doi.org/10.3390/curroncol29070372

AMA Style

Campos-Parra AD, Pérez-Quintanilla M, Martínez-Gutierrez AD, Pérez-Montiel D, Coronel-Martínez J, Millan-Catalan O, De León DC, Pérez-Plasencia C. Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers. Current Oncology. 2022; 29(7):4689-4702. https://doi.org/10.3390/curroncol29070372

Chicago/Turabian Style

Campos-Parra, Alma D., Milagros Pérez-Quintanilla, Antonio Daniel Martínez-Gutierrez, Delia Pérez-Montiel, Jaime Coronel-Martínez, Oliver Millan-Catalan, David Cantú De León, and Carlos Pérez-Plasencia. 2022. "Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers" Current Oncology 29, no. 7: 4689-4702. https://doi.org/10.3390/curroncol29070372

APA Style

Campos-Parra, A. D., Pérez-Quintanilla, M., Martínez-Gutierrez, A. D., Pérez-Montiel, D., Coronel-Martínez, J., Millan-Catalan, O., De León, D. C., & Pérez-Plasencia, C. (2022). Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers. Current Oncology, 29(7), 4689-4702. https://doi.org/10.3390/curroncol29070372

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