1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Global Cohort (n = 249) | Open Surgery (n = 184) | VATS (n = 65) | p-Value | |
---|---|---|---|---|
Age, years | 66 (58–72) | 66 (59–72) | 64 (50–72) | 0.21 |
Gender, females (%) | 67 (26.9) | 45 (24.5) | 22 (33.8) | 0.14 |
BMI | 25.4 ± 4.1 | 25.4 ± 4.1 | NA | NA |
Non-smokers, (%) | 48 (19.3) | 27 (14.7) | 21 (32.3) | 0.002 |
Pack Years | 37 (16–60) | 38 (17–60) | 31 (10–60) | 0.5 |
ASA score | I 89; II 83; | I 73; II 61; | I 16; II 22; | 0.085 |
III 60; NA 17 | III 38; NA 12 | III 22; NA 5 | <0.000001 | |
Surgery duration, hours | 3.0 (2.1–4.0) | 3.5 (2.5–4.5) | 2.0 (1.0–2.4) | <0.000001 |
Hospital Stay, days | 8.0 (5.0–10.0) | 9.0 (7.0–11.0) | 5.0 (3.0–6.5) | 0.036 |
Complications, (%) | 58 (23.3) | 49 (26.6) | 9 (13.8) | 0.21 |
Surgery Type | <0.0001 | |||
Lobectomy, n (%) | 139 (55.8) | 129 (70.1) | 10 (15.4) | |
Wedge resection, n (%) | 67 (26.9) | 31 (16.8) | 36 (55.4) | |
Pneumonectomy, n (%) | 9 (3.6) | 9 (4.9) | 0 (0) | |
Explorative procedure, n (%) | 17 (6.8) | 6 (3.2) | 11 (16.9) | |
Other, n (%) | 17 (6.8) | 9 (4.9) | 8 (12.3) | |
Blood Cell Count—Indexes | ||||
Lymphocytes, (×109/L) | 1.9 (1.5–2.4) | 1.9 (1.5–2.4) | 2.0 (1.5–2.5) | 0.77 |
Monocytes, (×109/L) | 0.5 (0.4–0.6) | 0.5 (0.4–0.7) | 0.4 (0.3–0.6) | 0.05 |
Neutrophils, (×109/L) | 4.6 (3.5–5.7) | 4.5 (3.5–5.7) | 4.7 (3.0–5.4) | 0.28 |
Platelets, (×109/L) | 255 (209–333) | 256 (210–333) | 248 (208–331) | 0.80 |
RDW, (fL) | 13.7 (12.9–14.8) | 13.8 (13.0–14.8) | 13.4 (12.7–14.8) | 0.16 |
MPV, (fL) | 8.3 (7.6–8.9) | 8.3 (7.7–9.0) | 8.1 (7.4–8.6) | 0.42 |
NLR | 2.3 (1.7–3.3) | 2.4 (1.7–3.3) | 2.0 (1.5–3.3) | 0.17 |
PLR | 137 (98–189) | 137 (101–188) | 139 (94–190) | 0.79 |
LMR | 4.4 (2.8–5.3) | 3.8 (2.8–5.0) | 4.5 (2.8–6.7) | 0.03 |
SIRI | 1.1 (0.7–1.8) | 1.2 (0.8–1.8) | 1.0 (0.5–1.7) | 0.05 |
AISI | 281 (163–565) | 316 (181–573) | 246 (121–448) | 0.05 |
Complications (All) | Complications (Open) | Complications (Vats) | ||
---|---|---|---|---|
NLR | Preoperative | rho = 0.00, p = 0.96 | rho = 0.03, p = 0.65 | rho = −0.18, p = 0.17 |
1st postop day | rho = −0.07, p = 0.29 | rho = −0.10, p = 0.19 | rho = 0.03, p = 0.84 | |
4th postop day | rho = 0.15, p = 0.03 | rho = 0.14, p = 0.07 | rho = 0.14, p = 0.37 | |
PLR | Preoperative | rho = 0.01, p = 0.87 | rho = 0.01, p = 0.88 | rho = 0.00, p = 0.92 |
1st postop day | rho = −0.03, p = 0.65 | rho = −0.04, p = 0.63 | rho = 0.02, p = 0.90 | |
4th postop day | rho = 0.10, p = 0.17 | rho = 0.09, p = 0.24 | rho = 0.12, p = 0.44 | |
LMR | Preoperative | rho = −0.03, p = 0.60 | rho = −0.06, p = 0.39 | rho = 0.13, p = 0.32 |
1st postop day | rho = 0.02, p = 0.74 | rho = 0.00, p = 0.96 | rho = 0.15, p = 0.26 | |
4th postop day | rho = −0.11, p = 0.10 | rho = −0.15, p = 0.048 | rho = 0.07, p = 0.63 | |
SIRI | Preoperative | rho = 0.27, p = 0.68 | rho = 0.07, p = 0.38 | rho = −0.18, p = 0.17 |
1st postop day | rho = −0.05, p = 0.43 | rho = −0.04, p = 0.61 | rho = −0.17, p = 0.22 | |
4th postop day | rho = 0.11, p = 0.12 | rho = 0.14, p = 0.07 | rho = −0.07, p = 0.63 | |
AISI | Preoperative | rho = 0.03, p = 0.68 | rho = 0.06, p = 0.40 | rho = −0.18, p = 0.17 |
1st postop day | rho = −0.02, p = 0.77 | rho = 0.00, p = 0.97 | rho = −0.10, p = 0.44 | |
4th postop day | rho = 0.09, p = 0.10 | rho = 0.13, p = 0.10 | rho = −0.04, p = 0.77 |
Hospital Stay (All) | Hospital Stay (Open) | Hospital Stay (VATS) | ||
---|---|---|---|---|
NLR | Preoperative | rho = 0.12, p = 0.06 | rho = 0.13, p = 0.08 | rho = 0.06, p = 0.67 |
1st postop day | rho = 0.24, p = 0.004 | rho = 0.16, p = 0.043 | rho = 0.12, p = 0.38 | |
4th postop day | rho = 0.23, p = 0.001 | rho = 0.19, p = 0.013 | rho= 0.10, p = 0.51 | |
PLR | Preoperative | rho = 0.04, p = 0.55 | rho = 0.04, p = 0.61 | rho = 0.16, p = 0.22 |
1st postop day | rho = 0.11, p = 0.10 | rho = 0.13, p = 0.09 | rho = 0.16, p = 0.23 | |
4th postop day | rho = 0.19, p = 0.007 | rho = 0.17, p = 0.03 | rho = 0.27, p = 0.07 | |
LMR | Preoperative | rho = −0.13, p = 0.046 | rho = −0.11, p = 0.13 | rho = 0.05, p = 0.71 |
1st postop day | rho = −0.16, p = 0.016 | rho = −0.15, p = 0.055 | rho = 0.02, p = 0.88 | |
4th postop day | rho = −0.11, p = 0.10 | rho = −0.11, p = 0.14 | rho = 0.11, p = 0.46 | |
SIRI | Preoperative | rho = 0.17, p = 0.008 | rho = 0.20, p = 0.009 | rho = 0.00, p = 0.97 |
1st postop day | rho = 0.21, p = 0.002 | rho = 0.21, p = 0.007 | rho = −0.02, p = 0.87 | |
4th postop day | rho = 0.17, p = 0.014 | rho = 0.17, p = 0.03 | rho = −0.14 p = 0.36 | |
AISI | Preoperative | rho = 0.18, p = 0.005 | rho = 0.21, p = 0.006 | rho = 0.06, p = 0.64 |
1st postop day | rho = 0.22, p = 0.001 | rho = 0.24, p = 0.002 | rho = 0.08, p = 0.55 | |
4th postop day | rho = 0.17, p = 0.01 | rho = 0.18, p = 0.02 | rho = −0.02, p = 0.88 |
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