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The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating Knowledge Users into Trial Design

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Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Box 511, Ottawa, ON K1H 8L6, Canada
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Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, 501 Smyth Road, Box 912, Ottawa, ON K1H 8L6, Canada
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Clinical Epidemiology Program, Ottawa Hospital Research Institute and University of Ottawa, 501 Smyth Road, Box 511, Ottawa, ON K1H 8L6, Canada
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Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(5), 3959-3977; https://doi.org/10.3390/curroncol28050337
Received: 27 July 2021 / Revised: 21 September 2021 / Accepted: 28 September 2021 / Published: 4 October 2021
(This article belongs to the Section Medical Oncology)
We reviewed patient and health care provider (HCP) surveys performed through the REaCT program. The REaCT team has performed 15 patient surveys (2298 respondents) and 13 HCP surveys (1033 respondents) that have addressed a broad range of topics in breast cancer management. Over time, the proportion of surveys distributed by paper/regular mail has fallen, with electronic distribution now the norm. For the patient surveys, the median duration of the surveys was 3 months (IQR 2.5–7 months) and the median response rate was 84% (IQR 80–91.7%). For the HCP surveys, the median survey duration was 3 months (IQR 1.75–4 months), and the median response rate, where available, was 28% (IQR 21.2–49%). The survey data have so far led to: 10 systematic reviews, 6 peer-reviewed grant applications and 19 clinical trials. Knowledge users should be an essential component of clinical research. The REaCT program has integrated surveys as a standard step of their trials process. The COVID-19 pandemic and reduced face-to-face interactions with patients in the clinic as well as the continued importance of social media highlight the need for alternative means of distributing and responding to surveys. View Full-Text
Keywords: breast cancer; knowledge users; patient centred outcomes; pragmatic trial breast cancer; knowledge users; patient centred outcomes; pragmatic trial
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MDPI and ACS Style

Saunders, D.; Liu, M.; Vandermeer, L.; Alzahrani, M.J.; Hutton, B.; Clemons, M. The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating Knowledge Users into Trial Design. Curr. Oncol. 2021, 28, 3959-3977. https://doi.org/10.3390/curroncol28050337

AMA Style

Saunders D, Liu M, Vandermeer L, Alzahrani MJ, Hutton B, Clemons M. The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating Knowledge Users into Trial Design. Current Oncology. 2021; 28(5):3959-3977. https://doi.org/10.3390/curroncol28050337

Chicago/Turabian Style

Saunders, Deanna, Michelle Liu, Lisa Vandermeer, Mashari J. Alzahrani, Brian Hutton, and Mark Clemons. 2021. "The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating Knowledge Users into Trial Design" Current Oncology 28, no. 5: 3959-3977. https://doi.org/10.3390/curroncol28050337

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