Next Article in Journal
Ampullary Carcinoma: An Overview of a Rare Entity and Discussion of Current and Future Therapeutic Challenges
Previous Article in Journal
Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core
Case Report

Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review

1
Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, Italy
2
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy
3
Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, Italy
4
School of Pathology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy
5
Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(5), 3384-3392; https://doi.org/10.3390/curroncol28050292
Received: 26 July 2021 / Revised: 24 August 2021 / Accepted: 26 August 2021 / Published: 31 August 2021
(This article belongs to the Section Thoracic Oncology)
We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohistochemical investigations, a diagnosis of breast metastasis from lung adenocarcinoma was made. This case emphasizes the importance of a comprehensive clinical, pathological, and molecular analysis in the differential diagnosis between primary breast cancer and metastases from extramammary tumor to guide adequate treatment decision making. View Full-Text
Keywords: EGFR-mutated lung adenocarcinoma; breast metastasis; lung neoplasms EGFR-mutated lung adenocarcinoma; breast metastasis; lung neoplasms
Show Figures

Figure 1

MDPI and ACS Style

Valenza, C.; Porta, F.M.; Rappa, A.; Guerini-Rocco, E.; Viale, G.; Barberis, M.; de Marinis, F.; Curigliano, G.; Catania, C. Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review. Curr. Oncol. 2021, 28, 3384-3392. https://doi.org/10.3390/curroncol28050292

AMA Style

Valenza C, Porta FM, Rappa A, Guerini-Rocco E, Viale G, Barberis M, de Marinis F, Curigliano G, Catania C. Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review. Current Oncology. 2021; 28(5):3384-3392. https://doi.org/10.3390/curroncol28050292

Chicago/Turabian Style

Valenza, Carmine, Francesca M. Porta, Alessandra Rappa, Elena Guerini-Rocco, Giuseppe Viale, Massimo Barberis, Filippo de Marinis, Giuseppe Curigliano, and Chiara Catania. 2021. "Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review" Current Oncology 28, no. 5: 3384-3392. https://doi.org/10.3390/curroncol28050292

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop