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Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core

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Department of Radiation Oncology, Hospital Sírio-Libanês, Rua Dona Adma Jajet 115, Sao Paulo 01308-050, Brazil
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Latin America Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, Brazil
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Academic Trials Promoting Team, Institut Jules Bordet, l’Université Libre de Bruxelles (U.L.B), 1210 Brussels, Belgium
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Radiation Oncology Unit, Santa Maria University Hospital (UFSM), Santa Maria 97105-900, Brazil
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Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry II, A-6020 Innsbruck, Austria
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Dendrix Research, Sao Paulo 04534-000, Brazil
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Palliative Care Research Unit, Department of Geriatrics and Palliative Medicine GP, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen NV, Denmark
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Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(5), 3373-3383; https://doi.org/10.3390/curroncol28050291
Received: 21 May 2021 / Revised: 6 August 2021 / Accepted: 26 August 2021 / Published: 31 August 2021
Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without chemotherapy was assessed. Translated EORTC CAT Core and all QLQ-C30 items were administered to patients using CHES (Computer-Based Health Evaluation System) before (T0) and after (T1) treatment initiation. The association between QLQ-C30 and CAT scores and ceiling/floor effects were estimated. Based on estimates of relative validity (cross-sectional, known-group differences and changes over time), relative sample-size requirements for CAT compared to QLQ-C30 were estimated. Results: Correlation coefficients between CAT and QLQ-C30 domains ranged from 0.63 to 0.93; except for dyspnoea, all coefficients were >0.82 (corresponding figures were 0.81–0.93 in the European study). On average across domains, floor/ceiling was reduced by 10% using CAT (9% in the European study) corresponding to a relative reduction of 32% (37% in the European study). Analyses of known-group validity and responsiveness indicated that, on average across domains, the sample-size requirements may be reduced by 17% using CAT rather than QLQ-C30, without loss of power (28% in the European study). The Brazilian sample had less symptom/quality of life impairment than the European sample, which likely explains the lower sample-size reduction using CAT when comparing with the European sample. Conclusions: The results in the Brazilian cohort were generally similar to those from the European sample and confirm the validity and usefulness of the EORTC CAT Core. View Full-Text
Keywords: health-related quality of life; treatment; patient-reported outcome measures; computerized adaptive test health-related quality of life; treatment; patient-reported outcome measures; computerized adaptive test
MDPI and ACS Style

Marta, G.N.; de Souza, T.Y.T.; Silva, A.R.N.d.S.e.; Pereira, A.P.A.; Ferreira Neto, D.R.; Asso, R.N.; Degrande, F.A.M.; Nader-Marta, G.; da Silva, M.F.; Gadia, R.; Hanna, S.A.; Holzner, B.; Saad, E.D.; Petersen, M.A. Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core. Curr. Oncol. 2021, 28, 3373-3383. https://doi.org/10.3390/curroncol28050291

AMA Style

Marta GN, de Souza TYT, Silva ARNdSe, Pereira APA, Ferreira Neto DR, Asso RN, Degrande FAM, Nader-Marta G, da Silva MF, Gadia R, Hanna SA, Holzner B, Saad ED, Petersen MA. Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core. Current Oncology. 2021; 28(5):3373-3383. https://doi.org/10.3390/curroncol28050291

Chicago/Turabian Style

Marta, Gustavo N., Tomás Y.T. de Souza, Alice R.N.d.S.e. Silva, Ana P.A. Pereira, David R. Ferreira Neto, Rie N. Asso, Fabiana A.M. Degrande, Guilherme Nader-Marta, Maurício F. da Silva, Rafael Gadia, Samir A. Hanna, Bernhard Holzner, Everardo D. Saad, and Morten A. Petersen 2021. "Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core" Current Oncology 28, no. 5: 3373-3383. https://doi.org/10.3390/curroncol28050291

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