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Article

Immunohistochemistry for Prostate Biopsy—Impact on Histological Prostate Cancer Diagnoses and Clinical Decision Making

1
Department of Urology, University Hospital Frankfurt, Goethe University Frankfurt, 60590 Frankfurt, Germany
2
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC H2X3A4, Canada
3
Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, Germany
4
Frankfurt Institute for Advanced Studies (FIAS), 60590 Frankfurt, Germany
5
Wildlab, University Hospital Frankfurt MVZ GmbH, 60590 Frankfurt, Germany
6
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany
7
Department of Urology, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Both authors contributed equally to the work.
Curr. Oncol. 2021, 28(3), 2123-2133; https://doi.org/10.3390/curroncol28030197
Received: 21 April 2021 / Revised: 15 May 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
(This article belongs to the Section Genitourinary Oncology)
Background: To test the value of immunohistochemistry (IHC) staining in prostate biopsies for changes in biopsy results and its impact on treatment decision-making. Methods: Between January 2017–June 2020, all patients undergoing prostate biopsies were identified and evaluated regarding additional IHC staining for diagnostic purpose. Final pathologic results after radical prostatectomy (RP) were analyzed regarding the effect of IHC at biopsy. Results: Of 606 biopsies, 350 (58.7%) received additional IHC staining. Of those, prostate cancer (PCa) was found in 208 patients (59.4%); while in 142 patients (40.6%), PCa could be ruled out through IHC. IHC patients harbored significantly more often Gleason 6 in biopsy (p < 0.01) and less suspicious baseline characteristics than patients without IHC. Of 185 patients with positive IHC and PCa detection, IHC led to a change in biopsy results in 81 (43.8%) patients. Of these patients with changes in biopsy results due to IHC, 42 (51.9%) underwent RP with 59.5% harboring ≥pT3 and/or Gleason 7–10. Conclusions: Patients with IHC stains had less suspicious characteristics than patients without IHC. Moreover, in patients with positive IHC and PCa detection, a change in biopsy results was observed in >40%. Patients with changes in biopsy results partly underwent RP, in which 60% harbored significant PCa. View Full-Text
Keywords: immunohistochemistry; IHC; prostate cancer; radical prostatectomy; ASAP; Gleason Score immunohistochemistry; IHC; prostate cancer; radical prostatectomy; ASAP; Gleason Score
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MDPI and ACS Style

Mandel, P.; Wenzel, M.; Hoeh, B.; Welte, M.N.; Preisser, F.; Inam, T.; Wittler, C.; Humke, C.; Köllermann, J.; Wild, P.; Würnschimmel, C.; Tilki, D.; Graefen, M.; Kluth, L.A.; Karakiewicz, P.I.; Chun, F.K.-H.; Becker, A. Immunohistochemistry for Prostate Biopsy—Impact on Histological Prostate Cancer Diagnoses and Clinical Decision Making. Curr. Oncol. 2021, 28, 2123-2133. https://doi.org/10.3390/curroncol28030197

AMA Style

Mandel P, Wenzel M, Hoeh B, Welte MN, Preisser F, Inam T, Wittler C, Humke C, Köllermann J, Wild P, Würnschimmel C, Tilki D, Graefen M, Kluth LA, Karakiewicz PI, Chun FK-H, Becker A. Immunohistochemistry for Prostate Biopsy—Impact on Histological Prostate Cancer Diagnoses and Clinical Decision Making. Current Oncology. 2021; 28(3):2123-2133. https://doi.org/10.3390/curroncol28030197

Chicago/Turabian Style

Mandel, Philipp; Wenzel, Mike; Hoeh, Benedikt; Welte, Maria N.; Preisser, Felix; Inam, Tahir; Wittler, Clarissa; Humke, Clara; Köllermann, Jens; Wild, Peter; Würnschimmel, Christoph; Tilki, Derya; Graefen, Markus; Kluth, Luis A.; Karakiewicz, Pierre I.; Chun, Felix K.-H.; Becker, Andreas. 2021. "Immunohistochemistry for Prostate Biopsy—Impact on Histological Prostate Cancer Diagnoses and Clinical Decision Making" Curr. Oncol. 28, no. 3: 2123-2133. https://doi.org/10.3390/curroncol28030197

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