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Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

1
Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
2
Oleander Medical Technologies, Baton Rouge, LA 70803, USA
3
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
4
Department of Radiology, West Virginia University Medical School, Morgantown, WV 26506, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(3), 2115-2122; https://doi.org/10.3390/curroncol28030196
Received: 22 April 2021 / Revised: 26 May 2021 / Accepted: 6 June 2021 / Published: 8 June 2021
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas. View Full-Text
Keywords: targeted osmotic lysis; advanced-stage cervical cancer; sodium channels; sodium pumps targeted osmotic lysis; advanced-stage cervical cancer; sodium channels; sodium pumps
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MDPI and ACS Style

Gould, H.J., III; Miller, P.R.; Edenfield, S.; Sherman, K.J.; Brady, C.K.; Paul, D. Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix. Curr. Oncol. 2021, 28, 2115-2122. https://doi.org/10.3390/curroncol28030196

AMA Style

Gould HJ III, Miller PR, Edenfield S, Sherman KJ, Brady CK, Paul D. Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix. Current Oncology. 2021; 28(3):2115-2122. https://doi.org/10.3390/curroncol28030196

Chicago/Turabian Style

Gould, Harry J., III; Miller, Paige R.; Edenfield, Samantha; Sherman, Kelly J.; Brady, Chad K.; Paul, Dennis. 2021. "Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix" Curr. Oncol. 28, no. 3: 2115-2122. https://doi.org/10.3390/curroncol28030196

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