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On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI

1
Department of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
2
Division of Neuropathology, University Hospital Leipzig, Liebigstraße 26, 04103 Leipzig, Germany
3
Institute of Neuroradiology, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Contributed equally.
Curr. Oncol. 2021, 28(2), 1437-1446; https://doi.org/10.3390/curroncol28020136
Received: 16 February 2021 / Revised: 28 March 2021 / Accepted: 2 April 2021 / Published: 7 April 2021
(This article belongs to the Section Neuro-Oncology)
Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated the prognostic value of several volumetric parameters derived from magnetic resonance imaging (MRI). Data from the Department of Neurosurgery, Leipzig University Hospital, were retrospectively analyzed. Patients treated between 2014 and 2019, aged older than 18 years and with adequate peri-operative MRI were included. Volumetric assessment was performed manually. One hundred and eighty-three patients were included. Survival of patients with mGBM was significantly shorter (p < 0.0001). Univariate analysis revealed extent of resection, adjuvant therapy regimen, residual tumor volume, tumor necrosis volume and ratio of tumor necrosis to initial volume as statistically significant for overall survival. In multivariate Cox regression, however, only EOR (for uGBM and the entire cohort) and adjuvant therapy were independently significant for survival. Decreased ratio of tumor necrosis to initial tumor volume and extent of resection were associated with prolonged survival in mGBM but failed to achieve statistical significance in multivariate analysis. View Full-Text
Keywords: glioblastoma; volumetric assessment; multifocal glioblastoma glioblastoma; volumetric assessment; multifocal glioblastoma
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MDPI and ACS Style

Kasper, J.; Hilbert, N.; Wende, T.; Fehrenbach, M.K.; Wilhelmy, F.; Jähne, K.; Frydrychowicz, C.; Hamerla, G.; Meixensberger, J.; Arlt, F. On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI. Curr. Oncol. 2021, 28, 1437-1446. https://doi.org/10.3390/curroncol28020136

AMA Style

Kasper J, Hilbert N, Wende T, Fehrenbach MK, Wilhelmy F, Jähne K, Frydrychowicz C, Hamerla G, Meixensberger J, Arlt F. On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI. Current Oncology. 2021; 28(2):1437-1446. https://doi.org/10.3390/curroncol28020136

Chicago/Turabian Style

Kasper, Johannes; Hilbert, Nicole; Wende, Tim; Fehrenbach, Michael K.; Wilhelmy, Florian; Jähne, Katja; Frydrychowicz, Clara; Hamerla, Gordian; Meixensberger, Jürgen; Arlt, Felix. 2021. "On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI" Curr. Oncol. 28, no. 2: 1437-1446. https://doi.org/10.3390/curroncol28020136

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