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Open AccessArticle

Clinicopathologic and Treatment Features of Long-Term Surviving Brain Metastasis Patients

1
Department of Radiation Oncology, University of Toronto, Toronto, ON M5G2M9, Canada
2
Radiation Medicine Program—Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada
3
Department of Medical Biophysics, University of Toronto, ON M5G2M9, Canada
4
Division of Neurosurgery—Toronto Western Hospital, University of Toronto, Toronto, ON M5G2M9, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(1), 549-559; https://doi.org/10.3390/curroncol28010054
Received: 17 November 2020 / Revised: 20 December 2020 / Accepted: 8 January 2021 / Published: 18 January 2021
Background: The purpose of our study was to characterize clinical features among brain metastasis (BM) patients who were long term survivors (LTS). Methods: We reviewed a registry of BM patients referred to our multidisciplinary BM clinic between 2006 and 2014 and identified 97 who lived ≥ 3 years following BM diagnosis. The clinical and treatment characteristics were obtained from a prospectively maintained database, and additional information was obtained through review of electronic medical records and radiologic images. Survival analyses were performed using the Kaplan-Meier method. Results: Median follow up for LTS was 67 months (range 36–181). Median age was 54 years, 65% had single BM, 39% had stable extracranial disease at the time of BM treatment, and brain was the first site of metastasis in 76%. Targetable mutations were present in 39% of patients and 66% received treatment with targeted-, hormonal-, or immuno-therapy. Brain surgery at the time of diagnosis was performed in 40% and stereotactic radiosurgery (SRS) or whole brain radiotherapy (alone or combination) in 52% and 56%, respectively. Following initial BM treatment, 5-year intracranial disease-free survival was 39%, and the cumulative incidence of symptomatic radio-necrosis was 16%. Five and ten-year overall survival was 72% and 26%, respectively. Conclusion: Most LTS were younger than 60 years old and had a single BM. Many received treatment with surgery or targeted, immune, or hormonal therapy. View Full-Text
Keywords: brain metastasis; long-term survivors; molecular characteristics; systemic therapy; targeted therapy; immunotherapy brain metastasis; long-term survivors; molecular characteristics; systemic therapy; targeted therapy; immunotherapy
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MDPI and ACS Style

Dasgupta, A.; Co, J.; Winter, J.; Millar, B.-A.; Laperriere, N.; Tsang, D.S.; van Prooijen, M.; Damyanovich, A.; Heaton, R.; Coolens, C.; Bernstein, M.; Kongkham, P.; Zadeh, G.; Berlin, A.; Conrad, T.; Moraes, F.Y.; Shultz, D.B. Clinicopathologic and Treatment Features of Long-Term Surviving Brain Metastasis Patients. Curr. Oncol. 2021, 28, 549-559. https://doi.org/10.3390/curroncol28010054

AMA Style

Dasgupta A, Co J, Winter J, Millar B-A, Laperriere N, Tsang DS, van Prooijen M, Damyanovich A, Heaton R, Coolens C, Bernstein M, Kongkham P, Zadeh G, Berlin A, Conrad T, Moraes FY, Shultz DB. Clinicopathologic and Treatment Features of Long-Term Surviving Brain Metastasis Patients. Current Oncology. 2021; 28(1):549-559. https://doi.org/10.3390/curroncol28010054

Chicago/Turabian Style

Dasgupta, Archya; Co, Jayson; Winter, Jeff; Millar, Barbara-Ann; Laperriere, Normand; Tsang, Derek S.; van Prooijen, Monique; Damyanovich, Andrei; Heaton, Robert; Coolens, Catherine; Bernstein, Mark; Kongkham, Paul; Zadeh, Gelareh; Berlin, Alejandro; Conrad, Tatiana; Moraes, Fabio Y.; Shultz, David B. 2021. "Clinicopathologic and Treatment Features of Long-Term Surviving Brain Metastasis Patients" Curr. Oncol. 28, no. 1: 549-559. https://doi.org/10.3390/curroncol28010054

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