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Current Oncology
Volume 27
Issue 5
10.3747/co.27.6751
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Article

A Pan-Canadian Prospective Study of Young Women with Breast Cancer: The Rationale and Protocol Design for the RUBY Study

by
M.L. Quan
1,2,3,*,
I.A. Olivotto
2,
N.N. Baxter
4,5,
C.M. Friedenreich
1,2,6,
K. Metcalfe
7,
E. Warner
8,
K. MacLennan
9,
J.E. Stephen
10,
M.R. Akbari
5,11,
D. Howell
6,
S. Narod
5,11 and
the RUBY site investigators
1
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
2
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
3
Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
4
Department of Surgery, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada
5
Women’s College Hospital, University of Toronto, Toronto, ON, Canada
6
Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, AB, Canada
7
Lawrence S. Bloomberg Faculty of Nursing, Alberta Health Services, Calgary, AB, Canada
8
Division of Medical Oncology, Sunnybrook Odette Cancer Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
9
Applied Health Research Centre (ahrc), Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
10
Clinical Neurosciences Program, Alberta Health Services, Calgary, AB, Canada
11
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
 
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*
Author to whom correspondence should be addressed.
Curr. Oncol. 2020, 27(5), 516-523; https://doi.org/10.3747/co.27.6751
Submission received: 11 July 2020 / Revised: 2 August 2020 / Accepted: 4 September 2020 / Published: 1 October 2020

Abstract

Introduction: The understanding of the biology and epidemiology of, and the optimal therapeutic strategies for, breast cancer (bca) in younger women is limited. We present the rationale, design, and initial recruitment of Reducing the Burden of Breast Cancer in Young Women (ruby), a unique national prospective cohort study designed to examine the diagnosis, treatment, quality of life, and outcomes from the time of diagnosis for young women with bca. Methods: Over a 4-year period at 33 sites across Canada, the ruby study will use a local and virtual recruitment model to enrol 1200 women with bca who are 40 years of age or younger at the time of diagnosis, before initiation of any treatment. At a minimum, comprehensive patient, tumour, and treatment data will be collected to evaluate recurrence and survival. Patients may opt to complete patient-reported questionnaires, to provide blood and tumour samples, and to be contacted for future research, forming the core dataset from which 4 subprojects evaluating genetics, lifestyle factors, fertility, and local management or delivery of care will be performed. Summary: The ruby study will be the most comprehensive repository of data, biospecimens, and patient-reported outcomes ever collected with respect to young women with bca from the time of diagnosis, enabling research unique to that population now and into the future. This research model could be used for other oncology settings in Canada.
Keywords: breast cancer; young-onset; prospective cohorts; pan-Canadian studies; knowledge translation; patient-reported outcomes; biorepositories breast cancer; young-onset; prospective cohorts; pan-Canadian studies; knowledge translation; patient-reported outcomes; biorepositories

Share and Cite

MDPI and ACS Style

Quan, M.L.; Olivotto, I.A.; Baxter, N.N.; Friedenreich, C.M.; Metcalfe, K.; Warner, E.; MacLennan, K.; Stephen, J.E.; Akbari, M.R.; Howell, D.; et al. A Pan-Canadian Prospective Study of Young Women with Breast Cancer: The Rationale and Protocol Design for the RUBY Study. Curr. Oncol. 2020, 27, 516-523. https://doi.org/10.3747/co.27.6751

AMA Style

Quan ML, Olivotto IA, Baxter NN, Friedenreich CM, Metcalfe K, Warner E, MacLennan K, Stephen JE, Akbari MR, Howell D, et al. A Pan-Canadian Prospective Study of Young Women with Breast Cancer: The Rationale and Protocol Design for the RUBY Study. Current Oncology. 2020; 27(5):516-523. https://doi.org/10.3747/co.27.6751

Chicago/Turabian Style

Quan, M.L., I.A. Olivotto, N.N. Baxter, C.M. Friedenreich, K. Metcalfe, E. Warner, K. MacLennan, J.E. Stephen, M.R. Akbari, D. Howell, and et al. 2020. "A Pan-Canadian Prospective Study of Young Women with Breast Cancer: The Rationale and Protocol Design for the RUBY Study" Current Oncology 27, no. 5: 516-523. https://doi.org/10.3747/co.27.6751

APA Style

Quan, M. L., Olivotto, I. A., Baxter, N. N., Friedenreich, C. M., Metcalfe, K., Warner, E., MacLennan, K., Stephen, J. E., Akbari, M. R., Howell, D., Narod, S., & the RUBY site investigators. (2020). A Pan-Canadian Prospective Study of Young Women with Breast Cancer: The Rationale and Protocol Design for the RUBY Study. Current Oncology, 27(5), 516-523. https://doi.org/10.3747/co.27.6751

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