Next Article in Journal
Cancer Evolution–Development: Experience of Hepatitis B Virus–Induced Hepatocarcinogenesis
Previous Article in Journal
In Vitro and In Vivo Studies on the Inhibitory Effects of Myocardial Cell Culture Medium on Growth of a Human Lung Adenocarcinoma Cell Line, A549
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 23
Issue 1
10.3747/co.23.2771
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Dosimetric and Clinical Toxicity Comparison of Critical Organ Preservation with Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, and RapidArc for the Treatment of Locally Advanced Cancer of the Pancreatic Head

by
L. Jin
1,2,
R. Wang
1,*,
S. Jiang
1,
J. Yue
1,
T. Liu
1,
X. Dou
1,
K. Zhu
1,
R. Feng
1,
X. Xu
1,
D. Chen
1,2 and
Y. Yin
1
1
Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, China
2
School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(1), 41-48; https://doi.org/10.3747/co.23.2771
Submission received: 4 November 2015 / Revised: 4 December 2015 / Accepted: 6 January 2016 / Published: 1 February 2016

Abstract

Purpose: We compared dosimetry and clinical toxicity for 3-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and RapidArc (Varian Medical Systems, Palo Alto, CA, U.S.A.) in locally advanced pancreatic cancer (LAPCC). We hypothesized that the technique with better sparing of organs at risk (OARs) and better target dose distributions could lead to decreased clinical toxicity. Methods: The study analyzed 280 patients with LAPCC who had undergone radiotherapy. The dosimetry comparison was performed using 20 of those patients. Dose–volume histograms for the target volume and the OARs were compared. The clinical toxicity comparison used the 280 patients who received radiation with 3D-CRT, IMRT, or RapidArc. Compared with 3D-CRT, RapidArc and IMRT both achieved a better conformal index, homogeneity index, V95%, and V110%. Results: Compared with 3D-CRT or IMRT, RapidArc reduced the V10, V20, and mean dose to duodenum, the V20 of the right kidney, and the liver mean dose. Compared with 3D-CRT, RapidArc reduced the V35, and V45 of duodenum, the mean dose to small bowel, and the V15 of right kidney. The incidences of grades 3 and 4 diarrhea (p = 0.037) and anorexia (p = 0.042) were lower with RapidArc than with 3D-CRT, and the incidences of grades 3 and 4 diarrhea (p = 0.027) were lower with RapidArc than with IMRT. Conclusions: Compared with 3D-CRT or IMRT, RapidArc showed better sparing of OARs, especially duodenum, small bowel, and right kidney. Also, fewer acute grades 3 and 4 gastrointestinal toxicities were seen with RapidArc than with 3D-CRT or IMRT. A technique with better sparing of OARs and better target dose distributions could result in decreased clinical toxicities during radiation treatment for LAPCC.
Keywords: Dosimetric comparisons; 3d-crt; imrt; RapidArc; pancreatic cancer; organ preservation Dosimetric comparisons; 3d-crt; imrt; RapidArc; pancreatic cancer; organ preservation

Share and Cite

MDPI and ACS Style

Jin, L.; Wang, R.; Jiang, S.; Yue, J.; Liu, T.; Dou, X.; Zhu, K.; Feng, R.; Xu, X.; Chen, D.; et al. Dosimetric and Clinical Toxicity Comparison of Critical Organ Preservation with Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, and RapidArc for the Treatment of Locally Advanced Cancer of the Pancreatic Head. Curr. Oncol. 2016, 23, 41-48. https://doi.org/10.3747/co.23.2771

AMA Style

Jin L, Wang R, Jiang S, Yue J, Liu T, Dou X, Zhu K, Feng R, Xu X, Chen D, et al. Dosimetric and Clinical Toxicity Comparison of Critical Organ Preservation with Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, and RapidArc for the Treatment of Locally Advanced Cancer of the Pancreatic Head. Current Oncology. 2016; 23(1):41-48. https://doi.org/10.3747/co.23.2771

Chicago/Turabian Style

Jin, L., R. Wang, S. Jiang, J. Yue, T. Liu, X. Dou, K. Zhu, R. Feng, X. Xu, D. Chen, and et al. 2016. "Dosimetric and Clinical Toxicity Comparison of Critical Organ Preservation with Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, and RapidArc for the Treatment of Locally Advanced Cancer of the Pancreatic Head" Current Oncology 23, no. 1: 41-48. https://doi.org/10.3747/co.23.2771

APA Style

Jin, L., Wang, R., Jiang, S., Yue, J., Liu, T., Dou, X., Zhu, K., Feng, R., Xu, X., Chen, D., & Yin, Y. (2016). Dosimetric and Clinical Toxicity Comparison of Critical Organ Preservation with Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, and RapidArc for the Treatment of Locally Advanced Cancer of the Pancreatic Head. Current Oncology, 23(1), 41-48. https://doi.org/10.3747/co.23.2771

Article Metrics

Back to TopTop