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Current Oncology
Volume 23
Issue 1
10.3747/co.23.2669
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer

by
S. Fu
1,
H. Tang
2,
Y. Liao
1,*,
Q. Xu
1,
C. Liu
1,
Y. Deng
1,
J. Wang
1,
J. Wang
1 and
X. Fu
1
1
Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2
Intensive Care Unit, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(1), 12-19; https://doi.org/10.3747/co.23.2669
Submission received: 9 November 2015 / Revised: 7 December 2015 / Accepted: 4 January 2016 / Published: 1 February 2016

Abstract

Objective: We explored the role of insulin-like growth factor 1 (igf-1) in the development of lung cancer. We used immunohistochemistry to measure the expression of igf-1 and igf-1 receptor (igf-1r) in specimens of tissue and perioperative circulation from 80 patients with primary non-small-cell lung cancer (nsclc) and from 45 patients with benign pulmonary lesions (bpls). Correlations of those measurements with clinicopathologic characteristics and clinical follow-up were analyzed. Circulating igf-1 was measured before and after surgery in all patients. Results: Compared with bpl specimens, nsclc specimens showed overexpression of igf-1 and igf-1r (p < 0.001). The expression levels of igf-1 and igf-1r were significantly associated with advanced-stage disease (p = 0.034 and 0.029 respectively) and lymph node metastasis (p = 0.012 and 0.017 respectively), and expression of igf-1 correlated with tumour differentiation and tumour diameter (p = 0.011 and 0.021 respectively). Specimens positive for igf-1 or igf-1r were significantly correlated with shorter patient survival (p = 0.0012 and 0.0016 respectively). After surgery, circulating igf-1 was significantly elevated in patients with bpl (p = 0.0346) and significantly lower in patients with nsclc (p = 0.0030), especially in those with advanced-stage disease, a larger tumour size, regional lymphoid node metastasis, or lesser differentiation (p = 0.0092, 0.0051, 0.0131, and p < 0.001 respectively). Conclusions: In nsclc, igf-1 and igf-1r are upregulated, and expression of those factors is correlated with tumour progression and prognosis in nsclc patients. Radical resection of nsclc can directly influence the serum concentration of igf-1. Autocrine/paracrine igf-1 might be playing an important role in the development of lung cancer.
Keywords: igf-1; igf-1r; non-small-cell lung cancer; immunohistochemistry; elisa igf-1; igf-1r; non-small-cell lung cancer; immunohistochemistry; elisa

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MDPI and ACS Style

Fu, S.; Tang, H.; Liao, Y.; Xu, Q.; Liu, C.; Deng, Y.; Wang, J.; Wang, J.; Fu, X. Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer. Curr. Oncol. 2016, 23, 12-19. https://doi.org/10.3747/co.23.2669

AMA Style

Fu S, Tang H, Liao Y, Xu Q, Liu C, Deng Y, Wang J, Wang J, Fu X. Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer. Current Oncology. 2016; 23(1):12-19. https://doi.org/10.3747/co.23.2669

Chicago/Turabian Style

Fu, S., H. Tang, Y. Liao, Q. Xu, C. Liu, Y. Deng, J. Wang, J. Wang, and X. Fu. 2016. "Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer" Current Oncology 23, no. 1: 12-19. https://doi.org/10.3747/co.23.2669

APA Style

Fu, S., Tang, H., Liao, Y., Xu, Q., Liu, C., Deng, Y., Wang, J., Wang, J., & Fu, X. (2016). Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer. Current Oncology, 23(1), 12-19. https://doi.org/10.3747/co.23.2669

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