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Current Oncology
Volume 22
Issue 1
10.3747/co.22.2392
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Clinical Challenges in Patients with Cancer-Associated Thrombosis: Canadian Expert Consensus Recommendations

by
M. Carrier
1,*,
A. Lazo-Langner
2,
S. Shivakumar
3,
V. Tagalakis
4,
P.L. Gross
5,
N. Blais
6,
C.A. Butts
7 and
M. Crowther
8
1
Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
2
Departments of Medicine, Oncology, and Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada
3
Department of Medicine, QEII Health Sciences Centre, Dalhousie University, Halifax, NS, Canada
4
Department of Medicine, Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Montreal, QC, Canada
5
Thrombosis and Atherosclerosis Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada
6
Department of Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada
7
Department of Oncology, University of Alberta, Edmonton, AB, Canada
8
St. Joseph’s Hospital, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2015, 22(1), 49-59; https://doi.org/10.3747/co.22.2392
Submission received: 3 November 2014 / Revised: 7 December 2014 / Accepted: 13 January 2015 / Published: 1 February 2015

Abstract

Venous thromboembolism is a common complication in cancer patients, and thromboembolism is the second most common cause of death after cancer progression. A number of clinical practice guidelines provide recommendations for the management of cancer-associated thrombosis. However, the guidelines lack recommendations covering commonly encountered clinical challenges (for example, thrombocytopenia, recurrent venous thromboembolism, etc.) for which little or no evidence exists. Accordingly, recommendations were developed to provide expert guidance to medical oncologists and other health care professionals caring for patients with cancer-associated thrombosis. The current expert consensus was developed by a team of 21 clinical experts. For each identified clinical challenge, the literature in MEDLINE, EMBASE, and Evidence Based Medicine Reviews was systematically reviewed. The quality of the evidence was assessed, summarized, and graded. Consensus statements were generated, and the experts voted anonymously using a modified Delphi process on their level of agreement with the various statements. Statements were progressively revised through separate voting iterations and were then finalized. Clinicians using these recommendations and suggestions should tailor patient management according to the risks and benefits of the treatment options, patient values and preferences, and local cost and resource allocations.
Keywords: venous thromboembolism; deep-vein thrombosis; pulmonary embolism; recommendations venous thromboembolism; deep-vein thrombosis; pulmonary embolism; recommendations

Share and Cite

MDPI and ACS Style

Carrier, M.; Lazo-Langner, A.; Shivakumar, S.; Tagalakis, V.; Gross, P.L.; Blais, N.; Butts, C.A.; Crowther, M. Clinical Challenges in Patients with Cancer-Associated Thrombosis: Canadian Expert Consensus Recommendations. Curr. Oncol. 2015, 22, 49-59. https://doi.org/10.3747/co.22.2392

AMA Style

Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Gross PL, Blais N, Butts CA, Crowther M. Clinical Challenges in Patients with Cancer-Associated Thrombosis: Canadian Expert Consensus Recommendations. Current Oncology. 2015; 22(1):49-59. https://doi.org/10.3747/co.22.2392

Chicago/Turabian Style

Carrier, M., A. Lazo-Langner, S. Shivakumar, V. Tagalakis, P.L. Gross, N. Blais, C.A. Butts, and M. Crowther. 2015. "Clinical Challenges in Patients with Cancer-Associated Thrombosis: Canadian Expert Consensus Recommendations" Current Oncology 22, no. 1: 49-59. https://doi.org/10.3747/co.22.2392

APA Style

Carrier, M., Lazo-Langner, A., Shivakumar, S., Tagalakis, V., Gross, P. L., Blais, N., Butts, C. A., & Crowther, M. (2015). Clinical Challenges in Patients with Cancer-Associated Thrombosis: Canadian Expert Consensus Recommendations. Current Oncology, 22(1), 49-59. https://doi.org/10.3747/co.22.2392

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